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Case Reports
. 2016 Jan-Apr;9(1):49-51.
doi: 10.4103/0974-620X.176101.

Organophosphate retinopathy

Hang Pham  1 , Michelle D Lingao  2 , Anuradha Ganesh  3 , Jenina E Capasso  4 , Rosanne Keep  5 , Karthikeyan A Sadagopan  6 , Alex V Levin  7
Affiliations
Case Reports

Organophosphate retinopathy

Hang Pham et al. Oman J Ophthalmol. 2016 Jan-Apr.

Abstract

Organophosphates have rarely been reported to cause various ocular sequelae including retinal degeneration. Retinal manifestations have been rarely reported and poorly characterized. We describe a case of a 76-year-old man with vision loss beginning in his 20s due to acute on chronic exposure to dimethoate, an organophosphate. He presented with bilateral geographic macular atrophy and midperipheral pigmentary clumping which we characterized by dilated fundoscopic examination, optical coherence tomography, and fundus autofluorescence.

Keywords: Organophosphate; pesticide; retinopathy.

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Figures

Figure 1
Figure 1
Fundus photography shows optic nerve pallor, retinal blood vessel attenuation, and macular geographic atrophy extending to the peripapillary region with pigmentary clumping
Figure 2
Figure 2
Fundus autofluorescence shows geographic and patchy hypoautofluorescence also involving the peripapillary area
Figure 3
Figure 3
Optical coherence tomography shows bilateral macular thinning and disruption of the photoreceptor-retinal pigmented epithelium complex with subretinal deposition
Figure 4
Figure 4
Intravenous fluorescein angiography shows a large area of macular atrophy and peripheral mottling of the retinal pigmented epithelium in both eyes
Figure 5
Figure 5
Audiogram demonstrates a downward slope indicating loss of sensitivity at high frequencies associated with presbycusis
See this image and copyright information in PMC

References

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