Editorial: Limbic Encephalitis: Autoimmune Impact on Inhibitory GABAergic Neuronal Pathways in Temporal Lobe Epilepsy
- PMID: 27014186
- PMCID: PMC4794484
- DOI: 10.3389/fneur.2016.00036
Editorial: Limbic Encephalitis: Autoimmune Impact on Inhibitory GABAergic Neuronal Pathways in Temporal Lobe Epilepsy
Keywords: B cells; T cells; encephalitis; epilepsy; limbic system; memory disorders; seizures; temporal lobe.
Similar articles
-
Diagnostic challenges in patients with temporal lobe seizures and features of autoimmune limbic encephalitis.Eur J Neurol. 2022 May;29(5):1303-1310. doi: 10.1111/ene.15026. Epub 2021 Jul 30. Eur J Neurol. 2022. PMID: 34288284
-
Limbic Encephalitis: Potential Impact of Adaptive Autoimmune Inflammation on Neuronal Circuits of the Amygdala.Front Neurol. 2015 Aug 3;6:171. doi: 10.3389/fneur.2015.00171. eCollection 2015. Front Neurol. 2015. PMID: 26284026 Free PMC article. Review.
-
Pre- and long-term postoperative courses of hippocampus-associated memory impairment in epilepsy patients with antibody-associated limbic encephalitis and selective amygdalohippocampectomy.Epilepsy Behav. 2018 Feb;79:93-99. doi: 10.1016/j.yebeh.2017.10.033. Epub 2017 Dec 16. Epilepsy Behav. 2018. PMID: 29253681
-
The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions.Neuroscience. 2016 Jan 15;312:86-98. doi: 10.1016/j.neuroscience.2015.11.008. Epub 2015 Nov 12. Neuroscience. 2016. PMID: 26582750
-
Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren's syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate blood brain barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and ataxia in animal models, and can be removed or silenced in some patients by immunotherapy.J Neural Transm (Vienna). 2014 Aug;121(8):1029-75. doi: 10.1007/s00702-014-1193-3. Epub 2014 Aug 1. J Neural Transm (Vienna). 2014. PMID: 25081016 Review.
References
LinkOut - more resources
Full Text Sources
Other Literature Sources