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. 2016 Jan 15:10:1-10.
doi: 10.2174/1874192401610010001. eCollection 2016.

Testosterone and Cardiovascular Disease

Amos Tambo  1 , Mohsin H K Roshan  1 , Nikolai P Pace  2
Affiliations

Testosterone and Cardiovascular Disease

Amos Tambo et al. Open Cardiovasc Med J. .

Abstract

Cardiovascular disease [CVD] is a leading cause of mortality accounting for a global incidence of over 31%. Atherosclerosis is the primary pathophysiology underpinning most types of CVD. Historically, modifiable and non-modifiable risk factors were suggested to precipitate CVD. Recently, epidemiological studies have identified emerging risk factors including hypotestosteronaemia, which have been associated with CVD. Previously considered in the realms of reproductive biology, testosterone is now believed to play a critical role in the cardiovascular system in health and disease. The actions of testosterone as they relate to the cardiac vasculature and its implication in cardiovascular pathology is reviewed.

Keywords: Atherosclerosis; Cardiovascular disease; Hypogonadism; Testosterone; Vascular biology.

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Figures

Fig. (1)
Fig. (1)
Summary diagram of the key roles of testosterone in cardiovascular system.
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References

    1. World Health Organization (WHO) Global status report on noncommunicable diseases 2014. 2014. pp. 1–302. Available at: http://www.who.int/nmh/publications/ncd-status-report-2014/en/
    1. Celermajer D.S., Ayer J.G. Childhood risk factors for adult cardiovascular disease and primary prevention in childhood. Heart. 2006;92(11):1701–1706. doi: 10.1136/hrt.2005.081760. - DOI - PMC - PubMed
    1. Fairweather D., Petri M.A., Coronado M.J., Cooper L.T. Autoimmune heart disease: role of sex hormones and autoantibodies in disease pathogenesis. Expert Rev. Clin. Immunol. 2012;8(3):269–284. doi: 10.1586/eci.12.10. - DOI - PMC - PubMed
    1. Oskui P.M., French W.J., Herring M.J., Mayeda G.S., Burstein S., Kloner R.A. Testosterone and the cardiovascular system: a comprehensive review of the clinical literature. J. Am. Heart Assoc. 2013;2(6):e000272. doi: 10.1161/JAHA.113.000272. - DOI - PMC - PubMed
    1. Nakashima Y., Wight T.N., Sueishi K. Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans. Cardiovasc. Res. 2008;79(1):14–23. doi: 10.1093/cvr/cvn099. - DOI - PubMed

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