The Molecular Harbingers of Early Mammalian Embryo Patterning
- PMID: 27015301
- DOI: 10.1016/j.cell.2016.03.005
The Molecular Harbingers of Early Mammalian Embryo Patterning
Abstract
Random or not, the mechanisms at play during the first cell-fate determination in mammalian embryos have been debated for years. Studies by Goolam et al. and White et al. shed new light on the molecular mechanisms underlying the intrinsic biases that lead to non-random lineage segregation in early mammalian development.
Copyright © 2016 Elsevier Inc. All rights reserved.
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Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos.Cell. 2016 Mar 24;165(1):61-74. doi: 10.1016/j.cell.2016.01.047. Cell. 2016. PMID: 27015307 Free PMC article.
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