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. 2016 Mar 24;165(1):15-17.
doi: 10.1016/j.cell.2016.03.002.

CASTORing New Light on Amino Acid Sensing

James E Hughes Hallett  1 , Brendan D Manning  2
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CASTORing New Light on Amino Acid Sensing

James E Hughes Hallett et al. Cell. .
Free article

Abstract

The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.

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