Review

. 2016 Jul;75(7):1417-8.

doi: 10.1136/annrheumdis-2016-209290. Epub 2016 Mar 25.

Replication of a distinct psoriatic arthritis risk variant at the IL23R locus

Ashley Budu-Aggrey¹, John Bowes², Sabine Loehr³, Steffen Uebe³, Maria I Zervou⁴, Philip Helliwell⁵, Anthony W Ryan⁶, David Kane⁷, Eleanor Korendowych⁸, Emiliano Giardina⁹, Jonathan Packham¹⁰, Ross McManus⁶, Oliver FitzGerald¹¹, Neil McHugh⁸, Frank Behrens¹², Harald Burkhardt¹², Ulrike Huffmeier³, Pauline Ho¹³, Javier Martin¹⁴, Santos Castañeda¹⁵, George Goulielmos⁴, Andre Reis³, Anne Barton¹⁶

Affiliations

¹ Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester, UK.
² Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK.
³ Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
⁴ Laboratory of Molecular Medicine and Human Genetics, Department of Internal Medicine, University of Crete, Heraklion, Greece.
⁵ NIHR-Leeds Musculoskeletal Biomedical Research Unit Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
⁶ Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.
⁷ Department of Rheumatology, Adelaide and Meath Hospital and Trinity College Dublin, Ireland.
⁸ Royal National Hospital for Rheumatic Diseases and Department Pharmacy and Pharmacology, University of Bath, Bath, UK.
⁹ Department of Biomedicine and Prevention, University of Rome 'Tor Vergata' and Laboratory of Molecular Genetics UILDM, Fondazione Santa Lucia IRCCS, Rome, Italy.
¹⁰ Rheumatology Department, Haywood Hospital, Health Services Research Unit, Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, UK.
¹¹ Department of Rheumatology, St. Vincent's University Hospital, UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
¹² Division of Rheumatology and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany.
¹³ Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.
¹⁴ CSIC, Instituto de Parasitologia y Biomedicina Lopez-Neyra, Granada, Spain.
¹⁵ Department of Rheumatology, Hospital La Princesa, IIS-IPrincesa, Madrid, Spain.
¹⁶ Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.

PMID: 27016051
PMCID: PMC4941176
DOI: 10.1136/annrheumdis-2016-209290

Review

Replication of a distinct psoriatic arthritis risk variant at the IL23R locus

Ashley Budu-Aggrey et al. Ann Rheum Dis. 2016 Jul.

. 2016 Jul;75(7):1417-8.

doi: 10.1136/annrheumdis-2016-209290. Epub 2016 Mar 25.

Authors

Affiliations

¹ Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester, UK.
² Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK.
³ Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
⁴ Laboratory of Molecular Medicine and Human Genetics, Department of Internal Medicine, University of Crete, Heraklion, Greece.
⁵ NIHR-Leeds Musculoskeletal Biomedical Research Unit Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
⁶ Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland.
⁷ Department of Rheumatology, Adelaide and Meath Hospital and Trinity College Dublin, Ireland.
⁸ Royal National Hospital for Rheumatic Diseases and Department Pharmacy and Pharmacology, University of Bath, Bath, UK.
⁹ Department of Biomedicine and Prevention, University of Rome 'Tor Vergata' and Laboratory of Molecular Genetics UILDM, Fondazione Santa Lucia IRCCS, Rome, Italy.
¹⁰ Rheumatology Department, Haywood Hospital, Health Services Research Unit, Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, UK.
¹¹ Department of Rheumatology, St. Vincent's University Hospital, UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
¹² Division of Rheumatology and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany.
¹³ Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.
¹⁴ CSIC, Instituto de Parasitologia y Biomedicina Lopez-Neyra, Granada, Spain.
¹⁵ Department of Rheumatology, Hospital La Princesa, IIS-IPrincesa, Madrid, Spain.
¹⁶ Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.

PMID: 27016051
PMCID: PMC4941176
DOI: 10.1136/annrheumdis-2016-209290

No abstract available

Keywords: Arthritis; Gene Polymorphism; Psoriatic Arthritis.

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Figures

**Figure 1**
(A) Association of *IL23R* variants in psoriatic arthritis (PsA) Immunochip study (1962 cases, 8923 controls). (B) Association of *IL23R* variants in psoriasis Immunochip study (2997 cases, 9183 controls). Credible single-nucleotide polymorphism sets are depicted below each plot for the rs12044149 (red) and rs9988642 (blue) association signals.

See this image and copyright information in PMC

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Replication of a distinct psoriatic arthritis risk variant at the IL23R locus

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Replication of a distinct psoriatic arthritis risk variant at the IL23R locus

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