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Comparative Study
. 2016 Jul;31(4):730-8.
doi: 10.3904/kjim.2014.328. Epub 2016 Mar 26.

Liver cirrhosis leads to poorer survival in patients with end-stage renal disease

Ae Jin Kim  1 , Hye Jin Lim  1 , Han Ro  1 , Ji Yong Jung  1 , Hyun Hee Lee  1 , Wookyung Chung  1 , Jae Hyun Chang  1
Affiliations
Comparative Study

Liver cirrhosis leads to poorer survival in patients with end-stage renal disease

Ae Jin Kim et al. Korean J Intern Med. 2016 Jul.

Abstract

Background/aims: Liver cirrhosis (LC) is an important problem in patients withend-stage renal disease (ESRD). Few studies have investigated the inf luence ofLC on mortality in patients with ESRD. This study investigated the associationbetween LC and mortality among patients with ESRD and compare mortality betweentwo dialysis modalities.

Methods: Adult patients (≥ 18 years of age) starting dialysis for ESRD were enrolledin the present study from 2000 to 2011. We analyzed 1,069 patients withESRD; of these, 742 patients were undergoing hemodialysis (HD) and 327 patientswere undergoing peritoneal dialysis (PD).

Results: The prevalence of LC was 44 of 1,069 patients (4.1%). The cumulative 1-,3-, and 5-year survival rates of noncirrhotic patients were 93%, 83%, and 73%, respectively,whereas the equivalent survival rates of cirrhotic patients were 90%,68%, and 48%, respectively (p = 0.011). After adjustment, LC was an independentrisk factor for death in patients with ESRD. No difference in mortality associatedwith LC was found between the HD and PD subgroups.

Conclusions: Of the patients with ESRD, cirrhotic patients had poorer survivalthan noncirrhotic patients. Among patients with ESRD and LC, survival of patientsundergoing PD may be comparable with that of patients undergoing HD.

Keywords: Hemodialysis; Liver cirrhosis; Mortality; Peritoneal dialysis.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1.
Figure 1.
All-cause mortality of noncirrhotic and cirrhotic patients with end-stage renal disease. Patients with liver cirrhosis (LC) had a higher mortality rate than those without LC (p = 0.011).
Figure 2.
Figure 2.
Survival of cirrhotic patients undergoing hemodialysis (HD) and peritoneal dialysis (PD). No difference in survival was observed according to dialysis modality in cirrhotic patients (p = 0.562).
See this image and copyright information in PMC

References

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