Transarterial Therapy for Colorectal Liver Metastases

Abstract

Until recently, hepatic arterial therapies (HAT) had been used for colorectal liver metastases after failure of first-, second-, and third-line chemotherapies. HAT has gained greater acceptance in patients with liver-dominant colorectal metastases after failure of surgery or systemic chemotherapy. The current data demonstrate that HAT is a safe and effective option for preoperative downsizing, optimizing the time to surgery, limiting non-tumor-bearing liver toxicity, and improving overall survival after surgery in patients with colorectal liver-only metastases. The aim of this review is to present the current data for HAT in liver-only and liver-dominant colorectal liver metastases.

Keywords: Chemoembolization; Colorectal liver metastases; Drug-eluting beads (DEB); Hepatic arterial therapy (HAT); Hepatic artery infusion (HAI); Surgical resection; Yttrium-90.