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. 2016 Sep;60(9):874-8.
doi: 10.1111/jir.12277. Epub 2016 Mar 28.

Population prevalence of Down's syndrome in the United Kingdom

M Alexander  1 , Y Ding  2 , N Foskett  1 , H Petri  3 , C Wandel  4 , O Khwaja  5
Affiliations

Population prevalence of Down's syndrome in the United Kingdom

M Alexander et al. J Intellect Disabil Res. 2016 Sep.

Abstract

Background: Aim was to estimate the age and sex-stratified prevalence of Down's syndrome (DS) in the United Kingdom (UK) general population using a large primary care database.

Method: Data source was the Clinical Practice Research Datalink. We divided the number of individuals with a record of DS present on 01/07/2014 by the total number of individuals, and computed Wilson's confidence intervals. Prevalence by age and sex was represented using local linear smoothing plots.

Results: On July 1(st) 2014, 1159 females and 1317 males with DS were present in the data, corresponding to a prevalence of 5.9 per 10 000 (95% CI: 5.5; 6.2) in females and 6.8 (6.5; 7.2) per 10 000 in males. Prevalence of DS was increased in individuals aged 40 to 55 years compared to adjacent age groups.

Conclusions: A relative peak prevalence of DS at age 40-55 years may be attributed to the combined effects of a rise in life expectancy and the still limited availability of selective abortion.

Keywords: Down's syndrome; prevalence; primary care database.

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