Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec;16(6):411-8.
doi: 10.2174/1389202916666150817202217.

The Developmental Origins of Osteoporosis

Claire L Wood  1 , Charlotte Stenson  2 , Nicholas Embleton  1
Affiliations

The Developmental Origins of Osteoporosis

Claire L Wood et al. Curr Genomics. 2015 Dec.

Abstract

Osteoporosis is one of the most prevalent skeletal disorders and has enormous public health consequences due to the morbidity and mortality of the resulting fractures. This article discusses the developmental origins of osteoporosis and outlines some of the modifiable and non-modifiable risk factors in both intrauterine and postnatal life that contribute to the later onset of osteoporosis. Evidence for the effects of birth size and early growth in both preterm and term born infants are discussed and the role of epigenetics within the programming hypothesis is highlighted. This review provides compelling evidence for the developmental origins of osteoporosis and highlights the importance of osteoporosis prevention at all stages of the life course.

Keywords: Bone mineral density; Life course; Osteoporosis.; Programming.

PubMed Disclaimer

Figures

Fig. (1)
Fig. (1)
Developmental origins of osteoporosis: conceptual model.
See this image and copyright information in PMC

References

    1. Consensus development conference Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am. J. Med. 1993;94(6):646–650. doi: 10.1016/0002-9343(93)90218-E. - DOI - PubMed
    1. Klotzbuecher C.M., Ross P.D., Landsman P.B., Abbott T.A., III, Berger M. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J. Bone Miner. Res. 2000;15(4):721–739. doi: 10.1359/jbmr.2000.15.4.721. - DOI - PubMed
    1. WHO. In Summary Meeting Report. Brussels, Belgium: World Health Organization; 2004. May 5-7, WHO scientific group on the assessment of osteoporosis at primary health care level.
    1. Johnell O., Kanis J.A. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos. Int. 2006;17(12):1726–1733. doi: 10.1007/s00198-006-0172-4. - DOI - PubMed
    1. Rigo J., Pieltain C., Salle B., Senterre J. Enteral calcium, phosphate and vitamin D requirements and bone mineralization in preterm infants. Acta Paediatr. 2007;96(7):969–974. doi: 10.1111/j.1651-2227.2007.00336.x. - DOI - PubMed

LinkOut - more resources