Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1989 Apr;3(2):166-74.
doi: 10.1007/BF00852901.

Proteinuria in a child with sialidosis: case report and histological studies

C E Kashtan  1 , T E Nevins, Z Posalaky, R L Vernier, A J Fish
Affiliations
Review

Proteinuria in a child with sialidosis: case report and histological studies

C E Kashtan et al. Pediatr Nephrol. 1989 Apr.

Abstract

A 9-year-old body with sialidosis had nephrotic-range proteinuria. Histological studies demonstrated massive distension of renal cells, particularly glomerular visceral epithelial cells, by cytoplasmic vesicles which contained material reactive with concanavalin A and wheat-germ agglutinin. In addition, some glomeruli exhibited segmental mesangial thickening or glomerulosclerosis. Ultrastructurally, focal detachment of visceral epithelial cells from the underlying glomerular basement membrane was observed. We postulate that glomerular visceral epithelial cell dysfunction may underlie the proteinuria and focal glomerulosclerosis exhibited by this patient. Hyperfiltration, as suggested by the child's elevated creatinine clearances, may be a contributing factor.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Eur J Biochem. 1977 May 16;75(2):391-403 - PubMed
    1. Biochim Biophys Acta. 1988 Apr 14;965(1):36-45 - PubMed
    1. Acta Neuropathol. 1986;71(3-4):278-84 - PubMed
    1. J Pediatr. 1984 Feb;104(2):225-31 - PubMed
    1. Kidney Int. 1982 Apr;21(4):565-74 - PubMed