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. 2016;9(2):53-57.
doi: 10.4172/jpb.1000389.

Proteomics Analysis of Brain Meningiomas in Pursuit of Novel Biomarkers of the Aggressive Behavior

Garni Barkhoudarian, Julian P Whitelegge, Daniel F Kelly, Margaret Simonian

Proteomics Analysis of Brain Meningiomas in Pursuit of Novel Biomarkers of the Aggressive Behavior

Garni Barkhoudarian et al. J Proteomics Bioinform. 2016.

Abstract

The aim of this pilot study was to evaluate the use of advanced proteomics techniques to identify novel protein markers that contribute to the transformation of benign meningiomas to more aggressive and malignant subtypes. Multiplex peptide stable isotope dimethyl labelling and nano-LCMS was used to identify and quantify the differentially expressed proteins in WHO Grade I, II and III meningioma tissues. The proteins identified will help elucidate the process of transformation to malignancy and may contribute to improved diagnosis and treatment of these aggressive tumors.

Keywords: Anaplastic meningioma; Atypical meningioma; Biomarkers; Meningioma; Proteomics.

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Figures

Figure 1
Figure 1
Histopathological progression of meningiomas from grade I (typical) to grade II (atypical) to grade III (anaplastic) subtypes. As the tumors become increasingly aggressive the cellularity increases, nuclear atypia formation and loss of cytoarchitecture.
Figure 2
Figure 2
Chart of the expression levels of selected proteins from Table 2. Their intensities in Ave control (C) and meningioma tissues (I, II and III).
See this image and copyright information in PMC

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