[Intestinal microbiota transplantation for the treatment of Clostridium difficile infection]

Abstract

The infections caused by C. difficile, responsible for the antibiotic-associated diarrhea and pseudomembranous colitis, are the growing health problem. An increasing number of C. difficile infection (CDI) cases and the phenomenon of multidrug-resistance of bacteria forces to find new, effective therapeutic methods. Intestinal microbiota transplantation ("fecal bacteriotherapy") is a promising remedy for patients suffering from recurrent, severe, not susceptible to standard treatments intestinal infection caused by C. difficile. Low cost, easy implementation and high efficiency at a short time treatment cause that it is a method increasingly tested and practiced by physicians. However, it is required to standardize the treatment procedure, as well as better understanding the biological mechanisms on which the treatment is based on.