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Review
. 2015;209(4):317-23.
doi: 10.1051/jbio/2016005. Epub 2016 Mar 28.

[Adaptation to the availability of essential amino-acids: role of GCN2/eIF2α/ATF4 pathway]

[Article in French]
Pierre Fafournoux, Julien Averous, Alain Bruhat, Valérie Carraro, Céline Jousse, Anne-Catherine Maurin, Florent Mesclon, Laurent Parry
Review

[Adaptation to the availability of essential amino-acids: role of GCN2/eIF2α/ATF4 pathway]

[Article in French]
Pierre Fafournoux et al. Biol Aujourdhui. 2015.

Abstract

In mammals, metabolic adaptations are required to overcome nutritional deprivation in amino-acids/proteins as well as episodes of malnutrition. GCN2 protein kinase, which phosphorylates the α subunit of the translation initiation factor eIF2, is a sensor of amino-acid(s) deficiencies. On one hand, this review briefly describes the main features of amino-acid metabolism. On the other hand, it describes the role of GCN2 in regulating numerous physiological functions.

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