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Case Reports
. 1989 Jul;3(3):314-6.
doi: 10.1007/BF00858540.

Nifedipine, verapamil and cyclosporin A pharmacokinetics in children

M R Ogborn  1 , J F Crocker, P C Grimm
Affiliations
Case Reports

Nifedipine, verapamil and cyclosporin A pharmacokinetics in children

M R Ogborn et al. Pediatr Nephrol. 1989 Jul.

Abstract

We report two paediatric renal transplant patients in whom interaction with the calcium channel blocking agent verapamil resulted in reduced cyclosporin A (CyA) elimination. Prior therapy with another calcium channel blocking agent, nifedipine, did not affect CyA pharmacokinetics. We speculate that verapamil reduced CyA elimination in children via an effect upon the microsomal oxidase system that is independent of calcium channel activity.

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References

    1. Lancet. 1986 Aug 30;2(8505):523 - PubMed
    1. Pediatr Nephrol. 1987 Apr;1(2):125-30 - PubMed
    1. Transplantation. 1987 Sep;44(3):395-401 - PubMed
    1. Transplant Proc. 1986 Dec;18(6 Suppl 5):50-5 - PubMed
    1. Biochem Pharmacol. 1985 Jul 15;34(14):2549-53 - PubMed

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