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. 2016 Aug;57 Suppl 1(Suppl 1):i83-i89.
doi: 10.1093/jrr/rrw022. Epub 2016 Mar 28.

An analysis of the structure of the compound biological effectiveness factor

Koji Ono  1
Affiliations

An analysis of the structure of the compound biological effectiveness factor

Koji Ono. J Radiat Res. 2016 Aug.

Abstract

This report is an analysis of the structure of the compound biological effectiveness (CBE) factor. The value of the CBE factor previously reported was revalued for the central nervous system, skin and lung. To describe the structure, the following terms are introduced: the vascular CBE (v-CBE), intraluminal CBE (il-CBE), extraluminal CBE (el-CBE) and non-vascular CBE (nv-CBE) factors and the geometric biological factor (GBF), i.e. the contributions that are derived from the total dose to the vasculature, each dose to vasculature from the intraluminal side and the extraluminal side, the dose to the non-vascular tissue and the factor to calculate el-CBE from il-CBE, respectively. The el-CBE factor element was also introduced to relate il-CBE to el-CBE factors. A CBE factor of 0.36 for disodium mercaptoundecahydrododecaborate (BSH) for the CNS was independent of the (10)B level in the blood; however, that for p-Boron-L-phenylalanine (BPA) increased with the (10)B level ratio of the normal tissue to the blood (N/B). The CBE factor was expressed as follows: factor = 0.32 + N/B × 1.65. The factor of 0.32 at 0 of N/B was close to the CBE factor for BSH. GBFs had similar values, between BSH and BPA, 1.39 and 1.52, respectively. The structure of the CBE factor for BPA to the lung was also elucidated based on this idea. The factor is described as follows: CBE factor = 0.32 + N/B × 1.80. By this elucidation of the structure of the CBE factor, it is expected that basic and clinical research into boron neutron capture therapy will progress.

Keywords: BPA; BSH; CBE factor; dermal necrosis; radiation myelopathy; radiation pneumonitis.

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Figures

Fig. 1.
Fig. 1.
Dose vs RBE of BMRR neutron beam. The author constructed the curve using the data in Table 1. The original data have been reported in the literature [18].
Fig. 2.
Fig. 2.
CBE factor for BSH to the CNS vs 10B level in the blood (ppm).
Fig. 3.
Fig. 3.
The correlation between the CBE factor for BPA to the CNS and the N/B of the 10B level before and after the adjustment of the RBE of the neutron beam.
Fig. 4.
Fig. 4.
The dissolution of the CBE factors for BSH and BPA to each component: il-CBE, el-CBE and nv-CBE and their elements.
Fig. 5.
Fig. 5.
The introduction of GBF to correlate el-CBE factor with il-CBE factor.
See this image and copyright information in PMC

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