Association of High Homocysteine Levels With the Risk Stratification in Hypertensive Patients at Risk of Stroke

Abstract

Purpose: We aimed to investigate the association between stroke morbidity and different stratifications of classic risk factors, such as increasing age, body mass index (BMI), blood lipids, and blood glucose, in hypertensive patients with high homocysteine levels.

Methods: A cross-sectional study of 2258 patients with primary hypertension were enrolled in this study, including 871 stroke cases (62.89%) in 1385 hypertensive patients without hyperhomocysteinemia (HHcy) and 647 (74.11%) stroke cases in 873 hypertensive patients with HHcy. Basic information of patients were collected, including age, sex, height, weight, smoking, alcohol consumption, and disease history. Blood chemical assays were performed to determine the levels of glucose, triglycerides, high-density lipoprotein cholesterol (HDL-C), total cholesterol, and homocysteine. Subsequently, comparison of stroke morbidity between the 2 groups was performed after the stratification of risk factors. Moreover, the correlation between the stroke morbidity and the risk factors was analyzed using a trend test in patients with H-type hypertension. Univariate and multivariate logistic regression analyses were used to evaluate the association between baseline factors and prevalence of stroke in H-type hypertensive patients.

Findings: After the stratification of risk factors, a statistical difference was noted in age (range, 45-74 yrs), glucose ranges (<6.1 and ≥7.0 mmol/L), BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), non-HDL-C, and triglyceride level of <200 mg/dL (P<0.05) in the H-type hypertension group compared with those in non-H-type hypertension group. Gradual elevation of stroke morbidity was identified with the increase of fasting glucose, SBP, and DBP. In multivariate logistic regression analysis, only higher SBP, DBP, fasting glucose level, homocysteine, and history of diabetes mellitus were the independent predictors for the stroke morbidity.

Implications: Comprehensive evaluation and strict management of multiple risk factors have become increasingly important in the alleviation of stroke morbidity for H-type hypertensive patients because these patients were more sensitive to the classic risk factors.

Keywords: homocysteine; hypertension; risk factors; stratification; stroke.