Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:2016:4980251.
doi: 10.1155/2016/4980251. Epub 2016 Feb 28.

The Correlation of Serum Myeloid-Related Protein-8/14 and Eosinophil Cationic Protein in Patients with Coronary Artery Disease

Guo-lian Xia  1 , Yun-kai Wang  1 , Zhao-quan Huang  1
Affiliations

The Correlation of Serum Myeloid-Related Protein-8/14 and Eosinophil Cationic Protein in Patients with Coronary Artery Disease

Guo-lian Xia et al. Biomed Res Int. 2016.

Abstract

Objective: To investigate the changes in serum Myeloid-Related Protein 8/14 (MRP8/14) and Eosinophil Cationic Protein (ECP) levels in patients with different types of coronary artery diseases (CAD) and assess the value of MRP8/14 and ECP detection in predicting CAD.

Methods: 178 patients were divided into CAD group including unstable angina pectoris (UAP), acute myocardial infarction (AMI), and stable angina pectoris (SAP). Thirty-six individuals with normal coronary artery served as the control group. Serum MRP8/14 and ECP were measured by ELISA. The severity of coronary artery stenosis was assessed by the numbers of involved coronary artery branches and the sum of Gensini scores.

Results: The MRP8/14 levels were significantly higher in AMI and UAP group than SAP and control group (P < 0.05). The levels of MRP8/14 in AMI group were also obviously higher than UAP group (P < 0.05). The ECP levels were obviously increased in AMI group, but there was no difference between SAP and UAP group (P > 0.05). The ECP was significantly increased in three impaired coronary arteries and obviously correlated with Gensini score (P < 0.01), whereas the MRP8/14 was obviously positively correlated with CRP (P < 0.01).

Conclusions: Increased MRP8/14 levels suggest the instability of the atherosclerotic plaque. ECP reflects the severity of coronary arteries stenosis, predicting atherosclerosis burden. They may become the new biomarkers of CAD.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of the MRP8/14 and ECP in four groups. Compared with controls, ∗ P < 0.05; compared with SAP group, # P < 0.05; compared with UAP group, ∧ P < 0.05.
Figure 2
Figure 2
Comparison of the MRP8/14 and ECP in four groups. Compared with controls, ∗ P < 0.05; compared with SVD or MVD group, # P < 0.05.
Figure 3
Figure 3
Correlation scatter diagram of MRP8/14 and hs-CRP (r = 0.731,  P < 0.05).
Figure 4
Figure 4
Correlation scatter diagram of ECP and Gensini (r = 0.546, P < 0.05).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mizuno Y., Jacob R. F., Mason R. P. Inflammation and the development of atherosclerosis. Journal of Atherosclerosis and Thrombosis. 2011;18(5):351–358. - PubMed
    1. Oktayoglu P., Bozkurt M., Mete N., Caglayan M., Em S., Nas K. Elevated serum levels of calprotectin (myeloid-related protein 8/14) in patients with ankylosing spondylitis and its association with disease activity and quality of life. The Journal of Investigative Medicine. 2014;62(6):880–884. doi: 10.1097/jim.0000000000000095. - DOI - PubMed
    1. Croce K., Gao H., Wang Y., et al. Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation. 2009;120(5):427–436. doi: 10.1161/circulationaha.108.814582. - DOI - PMC - PubMed
    1. Tagaya E., Kondo M., Kirishi S., Kawagoe M., Kubota N., Tamaoki J. Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma. Journal of Asthma. 2015;52(5):512–518. doi: 10.3109/02770903.2014.975358. - DOI - PubMed
    1. Ramarokoto C. E., Kildemoes A. O., Randrianasolo B. S., et al. Eosinophil granule proteins ECP and EPX as markers for a potential early-stage inflammatory lesion in Female Genital Schistosomiasis (FGS) PLoS Neglected Tropical Diseases. 2014;8(7) doi: 10.1371/journal.pntd.0002974.e2974 - DOI - PMC - PubMed