Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Mar 29:5:e15352.
doi: 10.7554/eLife.15352.

Thinking differently about lupus

Arthur Wuster  1 , Timothy W Behrens  1
Affiliations
Comment

Thinking differently about lupus

Arthur Wuster et al. Elife. .

Abstract

A search for the genetic causes of an autoimmune disease called systemic lupus erythematosus reveals a new twist on an old story.

Keywords: HLA; LD; SLE risk; evolutionary biology; genomics; haplotype; human; human biology; medicine; risk allele; targeted sequencing.

PubMed Disclaimer

Conflict of interest statement

AW, TWB are full-time employees of Genentech, Inc.

Comment on

  • Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.
    Raj P, Rai E, Song R, Khan S, Wakeland BE, Viswanathan K, Arana C, Liang C, Zhang B, Dozmorov I, Carr-Johnson F, Mitrovic M, Wiley GB, Kelly JA, Lauwerys BR, Olsen NJ, Cotsapas C, Garcia CK, Wise CA, Harley JB, Nath SK, James JA, Jacob CO, Tsao BP, Pasare C, Karp DR, Li QZ, Gaffney PM, Wakeland EK. Raj P, et al. Elife. 2016 Feb 15;5:e12089. doi: 10.7554/eLife.12089. Elife. 2016. PMID: 26880555 Free PMC article.

References

    1. Caffrey MFP, James DCO. Human lymphocyte antigen association in ankylosing spondylitis. Nature. 1973;242:121. doi: 10.1038/242121a0. - DOI - PubMed
    1. de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly MJ, Trowsdale J, Wijmenga C, Vyse TJ, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P, Rioux JD. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nature Genetics. 2006;38:1166–1172. doi: 10.1038/ng1885. - DOI - PMC - PubMed
    1. MHC Sequencing Consortium Complete sequence and gene map of a human major histocompatibility complex. the MHC sequencing consortium. Nature. 1999;401:921–923. doi: 10.1038/44853. - DOI - PubMed
    1. Raj P, Rai E, Song R, Khan S, Wakeland BE, Viswanathan K, Arana C, Liang C, Zhang B, Dozmorov I, Carr-Johnson F, Mitrovic M, Wiley GB, Kelly JA, Lauwerys BR, Olsen NJ, Cotsapas C, Garcia CK, Wise CA, Harley JB, Nath SK, James JA, Jacob CO, Tsao BP, Pasare C, Karp DR, Li QZ, Gaffney PM, Wakeland EK. Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity. eLife. 2016;5:e15352. doi: 10.7554/eLife.12089. - DOI - PMC - PubMed
    1. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SG. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Research. 2015;43:D423–431. doi: 10.1093/nar/gku1161. - DOI - PMC - PubMed

MeSH terms