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. 2016 Jul;23(4):796-801.
doi: 10.1093/jamia/ocw027. Epub 2016 Mar 28.

Developing knowledge resources to support precision medicine: principles from the Clinical Pharmacogenetics Implementation Consortium (CPIC)

James M Hoffman  1 , Henry M Dunnenberger  2 , J Kevin Hicks  3 , Kelly E Caudle  4 , Michelle Whirl Carrillo  5 , Robert R Freimuth  6 , Marc S Williams  7 , Teri E Klein  5 , Josh F Peterson  8
Affiliations

Developing knowledge resources to support precision medicine: principles from the Clinical Pharmacogenetics Implementation Consortium (CPIC)

James M Hoffman et al. J Am Med Inform Assoc. 2016 Jul.

Abstract

To move beyond a select few genes/drugs, the successful adoption of pharmacogenomics into routine clinical care requires a curated and machine-readable database of pharmacogenomic knowledge suitable for use in an electronic health record (EHR) with clinical decision support (CDS). Recognizing that EHR vendors do not yet provide a standard set of CDS functions for pharmacogenetics, the Clinical Pharmacogenetics Implementation Consortium (CPIC) Informatics Working Group is developing and systematically incorporating a set of EHR-agnostic implementation resources into all CPIC guidelines. These resources illustrate how to integrate pharmacogenomic test results in clinical information systems with CDS to facilitate the use of patient genomic data at the point of care. Based on our collective experience creating existing CPIC resources and implementing pharmacogenomics at our practice sites, we outline principles to define the key features of future knowledge bases and discuss the importance of these knowledge resources for pharmacogenomics and ultimately precision medicine.

Keywords: clinical decision support systems; electronic health records; knowledge bases; pharmacogenetics; precision medicine.

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Figures

Figure 1:
Figure 1:
Idealized information flow for querying pharmacogenomic knowledge resources and return to an EHR with CDS. aNumbers correspond with relevant principles. bEach knowledge component may be used alone or in combination depending on the clinical scenario. cAll resources listed are freely available (ClinGen, ClinVar, PharmGKB, and CPIC).
See this image and copyright information in PMC

References

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