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. 2017 May 9;8(19):30830-30843.
doi: 10.18632/oncotarget.8306.

Prediction of mycoplasma hominis proteins targeting in mitochondria and cytoplasm of host cells and their implication in prostate cancer etiology

Shahanavaj Khan  1   2 , Mohammed Zakariah  3 , Christian Rolfo  4 , Lembrechts Robrecht  4 , Sellappan Palaniappan  5
Affiliations

Prediction of mycoplasma hominis proteins targeting in mitochondria and cytoplasm of host cells and their implication in prostate cancer etiology

Shahanavaj Khan et al. Oncotarget. .

Abstract

Although the idea of bacteria causing different types of cancer has exploded about century ago, the potential mechanisms of carcinogenesis is still not well established. Many reports showed the involvement of M. hominis in the development of prostate cancer, however, mechanistic approach for growth and development of prostate cancer has been poorly understood. In the current study, we predicted M. hominis proteins targeting in the mitochondria and cytoplasm of host cells and their implication in prostate cancer. A total of 77 and 320 proteins from M. hominis proteome were predicted to target in the mitochondria and cytoplasm of host cells respectively. In particular, various targeted proteins may interfere with normal growth behaviour of host cells, thereby altering the decision of programmed cell death. Furthermore, we investigated possible mechanisms of the mitochondrial and cytoplasmic targeted proteins of M. hominis in etiology of prostate cancer by screening the whole proteome.

Keywords: M. hominis; cytoplasm; database; mitochondria; prostate cancer.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors do not have any potential conflicts of interest related to current work.

Figures

Figure 1
Figure 1. Summary of possible functions of Mycoplasma hominis proteins targeted to mitochondria and cytoplasm of the host cells in development of prostate cancer
See this image and copyright information in PMC

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