Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul;22(4):604-14.
doi: 10.1111/hae.12932. Epub 2016 Mar 31.

Declining trends in invasive orthopedic interventions for people with hemophilia enrolled in the Universal Data Collection program (2000-2010)

P Tobase  1 , H Lane  2 , A-E-A Siddiqi  3 , R Ingram-Rich  4 , R S Ward  5 ; Universal Data Collection Joint Outcome Working Group, Hemophilia Treatment Center Network (HTCN) Study Investigators
Affiliations

Declining trends in invasive orthopedic interventions for people with hemophilia enrolled in the Universal Data Collection program (2000-2010)

P Tobase et al. Haemophilia. 2016 Jul.

Abstract

Introduction: Recurrent joint hemarthroses due to hemophilia (Factor VIII and Factor IX deficiency) often lead to invasive orthopedic interventions to decrease frequency of bleeding and/or to alleviate pain associated with end-stage hemophilic arthropathy.

Aim: Identify trends in invasive orthopedic interventions among people with hemophilia who were enrolled in the Universal Data Collection (UDC) program during the period 2000-2010.

Methods: Data were collected from 130 hemophilia treatment centers in the United States annually during the period 2000-2010, in collaboration with the Centers for Disease Control and Prevention (CDC). The number of visits in which an invasive orthopedic intervention was reported was expressed as a proportion of the total visits in each year of the program. Invasive orthopedic interventions consisted of arthroplasty, arthrodesis, and synovectomy. Joints included in this study were the shoulder, elbow, hip, knee, and ankle.

Results: A 5.6% decrease in all invasive orthopedic interventions in all joints of people with hemophilia enrolled in the UDC program over the 11-year study period was observed.

Conclusions: These data reflect a declining trend in invasive orthopedic interventions in people with hemophilia. Further research is needed to understand the characteristics that may influence invasive orthopedic interventions.

Keywords: arthropathy; arthroplasty; hemophilia; orthopedic.

PubMed Disclaimer

Conflict of interest statement

Disclosures

PT received honoraria for speaking for Bayer Pharmaceuticals. HL received honoraria for speaking and consulting for Bayer and Baxter Pharmaceuticals. All other authors have no conflicts of interest that might be perceived as posing a conflict or bias.

Figures

Fig. 1
Fig. 1
All invasive orthopedic interventions (arthrodesis, arthroplasty, synovectomy, and other) summed over all joints. Other, represents a non-specific group of invasive orthopedic interventions not categorized as arthrodesis, arthroplasty or synovectomy.
Fig. 2
Fig. 2
All invasive orthopedic interventions (arthrodesis, arthroplasty, synovectomy, and other) by diagnosis. Other, represents a non-specific group of invasive orthopedic interventions not categorized as arthrodesis, arthroplasty or synovectomy.
Fig. 3
Fig. 3
All invasive orthopedic interventions (arthrodesis, arthroplasty, synovectomy, and other) by hemophilia severity. Figure excludes 75 individuals whose severity was unknown. Other, represents a non-specific group of invasive orthopedic interventions not categorized as arthrodesis, arthroplasty or synovectomy.
Fig. 4
Fig. 4
All invasive orthopedic interventions (arthrodesis, arthroplasty, synovectomy, and other) by age groups (in years). Other, represents a non-specific group of invasive orthopedic interventions not categorized as arthrodesis, arthroplasty or synovectomy.
Fig. 5
Fig. 5
All invasive orthopedic interventions (arthrodesis, arthroplasty, synovectomy, and other) by inhibitor status. Inhibitor negative is no reported inhibitor presence in the year prior to and year of an orthopedic intervention. Inhibitor positive is presence of inhibitor the year prior to and year of an orthopedic intervention. Other, represents a non-specific group of invasive orthopedic interventions not categorized as arthrodesis, arthroplasty or synovectomy.
Fig. 6
Fig. 6
All invasive orthopedic interventions (arthrodesis, arthroplasty, synovectomy, and other) by factor use. ‘On demand’ is defined as intermittent use of factor replacement as recorded by the Universal Data Collection (UDC) program in the year prior to and year of an invasive orthopedic intervention. Continuous prophylaxis is defined recorded continuous prophylaxis by the UDC program in the year prior to and year of an invasive orthopedic intervention. Other, represents a non-specific group of invasive orthopedic interventions not categorized as arthrodesis, arthroplasty or synovectomy.
See this image and copyright information in PMC

References

    1. Klamroth R, Pollmann H, Hermans C, et al. The relative burden of haemophilia A and the impact of target joint development on health-related quality of life: results from the ADVATE Post-Authorization Safety Surveillance (PASS) study. Haemophilia. 2011;17:412–21. - PubMed
    1. Soucie JM, McAlister S, McClellan A, Oakley M, Su Y. The universal data collection surveillance system for rare bleeding disorders. Am J Prev Med. 2010;38:S475–81. - PubMed
    1. Rahme M, Ehlinger M, Faradji A, et al. Total knee arthroplasty in severe haemophilic patients under continuous infusion of clotting factors. Knee Surg Sports Traumatol Arthrosc. 2012;20:1781–6. - PubMed
    1. Rodriguez-Merchan EC. Aspects of current management: orthopaedic surgery in haemophilia. Haemophilia. 2012;18:8–16. - PubMed
    1. Goddard NJ, Rodriguez-Merchan EC, Wiedel JD. Total knee replacement in haemophilia. Haemophilia. 2002;8:382–6. - PubMed