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Meta-Analysis
. 2016 Mar 31;11(3):e0151607.
doi: 10.1371/journal.pone.0151607. eCollection 2016.

Prevalence and Geographical Variation of Prothrombin G20210A Mutation in Patients with Cerebral Vein Thrombosis: A Systematic Review and Meta-Analysis

Joaquín V Gonzalez  1 , Andrés G Barboza  2   3 , Fernando J Vazquez  4   5 , Esteban Gándara  6   7   8
Affiliations
Meta-Analysis

Prevalence and Geographical Variation of Prothrombin G20210A Mutation in Patients with Cerebral Vein Thrombosis: A Systematic Review and Meta-Analysis

Joaquín V Gonzalez et al. PLoS One. .

Abstract

Objectives: To compare the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis against healthy controls, and evaluate geographical variations.

Design: Systematic review and meta-analysis of case control studies.

Methods: We conducted a systematic review of electronic databases including MEDLINE and EMBASE. The main outcome was the prevalence of prothrombin G20210A in patients with objectively confirmed cerebral vein or cortical vein thrombosis; we also analyzed individual country variations in the prevalence. The random-effects model OR was used as the primary outcome measure.

Results: In total 19 studies evaluated 868 cases of cerebral venous thrombosis and 3981 controls. Prothrombin G20210A was found in 103/868 of the patients with cerebral venous thrombosis and 105/3999 of the healthy controls [random effects pooled OR 5.838, 95% CI 3.96 to 8.58; I217.9%]. The prevalence of prothrombin G20210A was significantly elevated in Italian studies (OR 9.69), in Brazilian studies (OR 7.02), and in German studies (OR 3.77), but not in Iranian studies (OR 0.98).

Conclusion: Prothrombin G20210A is significantly associated with cerebral venous thrombosis when compared to healthy controls, although this association is highly dependent on the country of origin.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram.
Fig 2
Fig 2. Forest plot prevalence of prothrombin G20210A.
Fig 3
Fig 3. Bias assessment plot.
Fig 4
Fig 4. L’Abbé bias plot.
See this image and copyright information in PMC

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