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. 1989 Mar;81(4):308-10.
doi: 10.1007/BF00283680.

Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM)

H G Brunner  1 , R G Korneluk, M Coerwinkel-Driessen, A MacKenzie, H Smeets, H M Lambermon, B A van Oost, B Wieringa, H H Ropers
Affiliations

Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM)

H G Brunner et al. Hum Genet. 1989 Mar.

Abstract

We have studied genetic linkage between the gene for creatine kinase muscle type (CKMM) and the gene for myotonic dystrophy (DM). In a panel of 65 myotonic dystrophy families from Canada and the Netherlands, a maximum lod score (Zmax) of 22.8 at a recombination frequency (theta) of 0.03 was obtained. Tight linkage was also demonstrated for CKMM and the gene for apolipoprotein C2 (ApoC2). This establishes CKMM as a useful marker for myotonic dystrophy.

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