Thyroid Hormones as Renal Cell Cancer Regulators

doi:10.1155/2016/1362407

Review

. 2016:2016:1362407.

doi: 10.1155/2016/1362407. Epub 2016 Mar 13.

Thyroid Hormones as Renal Cell Cancer Regulators

Łukasz Szymański¹, Damian Matak², Ewa Bartnik³, Cezary Szczylik⁴, Anna M Czarnecka⁴

Affiliations

¹ Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland; Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland.
² Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland; School of Molecular Medicine, Medical University of Warsaw, Zwirki i Wigury 61, 02-091 Warsaw, Poland.
³ Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland; Institute of Biochemistry and Biophysics, Pawinskiego 5a, 02-106 Warsaw, Poland.
⁴ Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.

PMID: 27034829
PMCID: PMC4808550
DOI: 10.1155/2016/1362407

Review

Thyroid Hormones as Renal Cell Cancer Regulators

Łukasz Szymański et al. J Signal Transduct. 2016.

. 2016:2016:1362407.

doi: 10.1155/2016/1362407. Epub 2016 Mar 13.

Authors

Łukasz Szymański¹, Damian Matak², Ewa Bartnik³, Cezary Szczylik⁴, Anna M Czarnecka⁴

Affiliations

¹ Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland; Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland.
² Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland; School of Molecular Medicine, Medical University of Warsaw, Zwirki i Wigury 61, 02-091 Warsaw, Poland.
³ Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland; Institute of Biochemistry and Biophysics, Pawinskiego 5a, 02-106 Warsaw, Poland.
⁴ Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.

PMID: 27034829
PMCID: PMC4808550
DOI: 10.1155/2016/1362407

Abstract

It is known that thyroid hormone is an important regulator of cancer development and metastasis. What is more, changes across the genome, as well as alternative splicing, may affect the activity of the thyroid hormone receptors. Mechanism of action of the thyroid hormone is different in every cancer; therefore in this review thyroid hormone and its receptor are presented as a regulator of renal cell carcinoma.

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Figures

**Figure 1**
Thyroid hormone-signaling pathway.

See this image and copyright information in PMC

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References

1. Definition of Renal Cell Cancer—NCI Dictionary of Cancer Terms, National Cancer Institute, http://www.cancer.gov/dictionary.
1. Chow W.-H., Dong L. M., Devesa S. S. Epidemiology and risk factors for kidney cancer. Nature Reviews Urology. 2010;7(5):245–257. doi: 10.1038/nrurol.2010.46. - DOI - PMC - PubMed
1. Buczek M., Escudier B., Bartnik E., Szczylik C., Czarnecka A. Resistance to tyrosine kinase inhibitors in clear cell renal cell carcinoma: from the patient's bed to molecular mechanisms. Biochimica et Biophysica Acta—Reviews on Cancer. 2014;1845(1):31–41. doi: 10.1016/j.bbcan.2013.10.001. - DOI - PubMed
1. Cheville J. C., Lohse C. M., Zincke H., Weaver A. L., Blute M. L. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. American Journal of Surgical Pathology. 2003;27(5):612–624. doi: 10.1097/00000478-200305000-00005. - DOI - PubMed
1. Mattei J., da Silva R. D., Sehrt D., Molina W. R., Kim F. J. Targeted therapy in metastatic renal carcinoma. Cancer Letters. 2014;343(2):156–160. doi: 10.1016/j.canlet.2013.09.038. - DOI - PubMed

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[1] Definition of Renal Cell Cancer—NCI Dictionary of Cancer Terms, National Cancer Institute, http://www.cancer.gov/dictionary.

[2] Definition of Renal Cell Cancer—NCI Dictionary of Cancer Terms, National Cancer Institute, http://www.cancer.gov/dictionary.

[3] Chow W.-H., Dong L. M., Devesa S. S. Epidemiology and risk factors for kidney cancer. Nature Reviews Urology. 2010;7(5):245–257. doi: 10.1038/nrurol.2010.46. - DOI - PMC - PubMed

[4] Chow W.-H., Dong L. M., Devesa S. S. Epidemiology and risk factors for kidney cancer. Nature Reviews Urology. 2010;7(5):245–257. doi: 10.1038/nrurol.2010.46. - DOI - PMC - PubMed

[5] Buczek M., Escudier B., Bartnik E., Szczylik C., Czarnecka A. Resistance to tyrosine kinase inhibitors in clear cell renal cell carcinoma: from the patient's bed to molecular mechanisms. Biochimica et Biophysica Acta—Reviews on Cancer. 2014;1845(1):31–41. doi: 10.1016/j.bbcan.2013.10.001. - DOI - PubMed

[6] Buczek M., Escudier B., Bartnik E., Szczylik C., Czarnecka A. Resistance to tyrosine kinase inhibitors in clear cell renal cell carcinoma: from the patient's bed to molecular mechanisms. Biochimica et Biophysica Acta—Reviews on Cancer. 2014;1845(1):31–41. doi: 10.1016/j.bbcan.2013.10.001. - DOI - PubMed

[7] Cheville J. C., Lohse C. M., Zincke H., Weaver A. L., Blute M. L. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. American Journal of Surgical Pathology. 2003;27(5):612–624. doi: 10.1097/00000478-200305000-00005. - DOI - PubMed

[8] Cheville J. C., Lohse C. M., Zincke H., Weaver A. L., Blute M. L. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. American Journal of Surgical Pathology. 2003;27(5):612–624. doi: 10.1097/00000478-200305000-00005. - DOI - PubMed

[9] Mattei J., da Silva R. D., Sehrt D., Molina W. R., Kim F. J. Targeted therapy in metastatic renal carcinoma. Cancer Letters. 2014;343(2):156–160. doi: 10.1016/j.canlet.2013.09.038. - DOI - PubMed

[10] Mattei J., da Silva R. D., Sehrt D., Molina W. R., Kim F. J. Targeted therapy in metastatic renal carcinoma. Cancer Letters. 2014;343(2):156–160. doi: 10.1016/j.canlet.2013.09.038. - DOI - PubMed

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Thyroid Hormones as Renal Cell Cancer Regulators

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Thyroid Hormones as Renal Cell Cancer Regulators

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