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Editorial
. 2016 Apr 12;113(15):3918-20.
doi: 10.1073/pnas.1602650113. Epub 2016 Mar 24.

Enhanced gene targeting to evaluate Lynch syndrome alterations

Richard Fishel  1 , Christopher D Heinen  2
Affiliations
Editorial

Enhanced gene targeting to evaluate Lynch syndrome alterations

Richard Fishel et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The location of MSH2 variants of unknown significance on the MSH2–MSH6 protein structure. The MSH2 class 3 VUS from the InSIGHT Colon Cancer Gene Variant Database (9) were mapped to their location (green dots) on the MSH2 (purple)–MSH6 (blue) structure bound to a DNA mismatch (22).
See this image and copyright information in PMC

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References

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    1. Loeb LA. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 1991;51(12):3075–3079. - PubMed

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