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Review
. 2015 Dec;27(6):388-96.
doi: 10.1016/j.smim.2016.03.012. Epub 2016 Mar 31.

Dendritic cell development-History, advances, and open questions

Sarah Puhr  1 , Jaeyop Lee  2 , Ekaterina Zvezdova  3 , Yu J Zhou  4 , Kang Liu  5
Affiliations
Review

Dendritic cell development-History, advances, and open questions

Sarah Puhr et al. Semin Immunol. 2015 Dec.

Abstract

Dendritic cells (DCs) are uniquely potent in orchestrating T cell immune response, thus they are indispensable immune sentinels. They originate from progenitors in the bone marrow through hematopoiesis, a highly regulated developmental process involving multiple cellular and molecular events. This review highlights studies of DC development-from the discovery of DCs as glass-adherent antigen presenting cells to the debate and resolution of their origin and lineage map. In particular, we summarize the roles of lineage-specific cytokines, the placement of distinct hematopoietic progenitors within the DC lineage and transcriptional programs governing DC development, which together have allowed us to diagram the current view of DC hematopoiesis. Important open questions and debates on the DC development and relevant models are also discussed.

Keywords: CDP; Cytokine; Dendritic cell; Hematopoiesis; Lineage; MDP; Mononuclear phagocyte system; Pre-cDC; Progenitor; Transcription factor.

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Figures

Figure 1
Figure 1
Phenotype and relationship of DC progenitors in mouse
Figure 2
Figure 2
Phenotype and relationship of DC progenitors in human
See this image and copyright information in PMC

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