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Review
. 2016 Jun;18(6):38.
doi: 10.1007/s11936-016-0461-y.

Hippo/Yap Signaling in Cardiac Development and Regeneration

Yang Xiao  1   2 , John Leach  1 , Jun Wang  1 , James F Martin  3   4   5   6   7
Affiliations
Review

Hippo/Yap Signaling in Cardiac Development and Regeneration

Yang Xiao et al. Curr Treat Options Cardiovasc Med. 2016 Jun.

Abstract

The heart has historically been considered to be a non-regenerative organ. Recent insights have suggested that cardiomyocytes have a small but measurable ability to regenerate. Moreover, recent work has also shown that manipulating the expression of specific genetic pathways can improve the ability of the heart to repair itself. These new insights set the stage for the development of new treatments for heart failure.

Keywords: Cardiac development; Cardiac regeneration; Hippo/Yap signaling.

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