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. 2016 Jun;29(3):487-94.
doi: 10.1007/s10534-016-9930-8. Epub 2016 Apr 4.

Does titanium in ionic form display a tissue-specific distribution?

Magdalena Golasik  1 , Pawel Wrobel  2 , Magdalena Olbert  3 , Barbara Nowak  4 , Mateusz Czyzycki  2   5 , Tadeusz Librowski  3 , Marek Lankosz  2 , Wojciech Piekoszewski  6   7
Affiliations

Does titanium in ionic form display a tissue-specific distribution?

Magdalena Golasik et al. Biometals. 2016 Jun.

Abstract

Most studies have focused on the biodistribution of titanium(IV) oxide as nanoparticles or crystals in organism. But several reports suggested that titanium is released from implant in ionic form. Therefore, gaining insight into toxicokinetics of Ti ions will give valuable information, which may be useful when assessing the health risks of long-term exposure to titanium alloy implants in patients. A micro synchrotron radiation-induced X-ray fluorescence (µ-SRXRF) was utilized to investigate the titanium distribution in the liver, spleen and kidneys of rats following single intravenous or 30-days oral administration of metal (6 mg Ti/b.w.) in ionic form. Titanium was mainly retained in kidneys after both intravenous and oral dosing, and also its compartmentalization in this organ was observed. Titanium in the liver was non-uniformly distributed-metal accumulated in single aggregates, and some of them were also enriched in calcium. Correlation analysis showed that metal did not displace essential elements, and in liver titanium strongly correlated with calcium. Two-dimensional maps of Ti distribution show that the location of the element is characteristic for the route of administration and time of exposure. We demonstrated that µ-SRXRF can provide information on the distribution of titanium in internal structures of whole organs, which helps in enhancing our understanding of the mechanism of ionic titanium accumulation in the body. This is significant due to the popularity of titanium implants and the potential release of metal ions from them to the organism.

Keywords: Micro synchrotron radiation-induced X-ray fluorescence; Organ distribution; Rat tissues; Titanium.

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Figures

Fig. 1
Fig. 1
Distribution of titanium in thin sections of median (a), left lateral (b) and right lateral (c) lobes of rat liver at 180 min after injection of single dose of titanium citrate. Data are presented in µg cm−2
Fig. 2
Fig. 2
Distribution of titanium in thin sections of liver collected from animals after 30-days oral exposure to Ti (a), at 30 min (b) and 180 min (c) after injection of single dose of titanium citrate. Data are presented in µg cm−2 (log scale)
Fig. 3
Fig. 3
Distribution of titanium in thin sections of kidney collected from animals after 30-days oral exposure to Ti (a), at 30 min (b) and 180 min (c) after injection of a single dose of titanium salt. Data are presented in µg cm−2
Fig. 4
Fig. 4
Distribution of titanium in thin sections of spleen collected from animals after 30-days oral exposure to Ti (a), at 30 min (b) and 180 min (c) after injection of single dose of titanium salt. Data are presented in µg cm−2
See this image and copyright information in PMC

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