Susceptible gene polymorphisms for blood stasis syndrome of coronary heart disease

Abstract

Coronary heart disease (CHD) is a typically polygenic and multi-factorial disease. Recent advances have proposed the hypothesis that multiple polymorphisms in the presence of environmental factors could act synergistically in the pathogenesis of CHD. Lots of gene polymorphisms related with CHD have been discovered by genome-wide linkage (in families) and association (in populations) studies. A key issue now is to move from mapping gene polymorphisms to pinpointing causal genes and variants, and to develop a molecular understanding of how these genes lead to CHD. New thinking needs to be brought in for resolving this problem. The benefifit of Chinese medicine (CM) in CHD has been proven by more and more clinical evidences. More importantly, linking CM syndrome differentiation and biomedical diagnosis might help further accurate stratifification of CHD patients for intervention selection. The epidemiological investigation has demonstrated that blood stasis syndrome (BSS) is the major CM syndrome type of CHD. BSS is a kind of pathological state caused by disturbance of blood circulation. Clinical studies indicate that the severity of BSS is related with the severity of CHD and BSS of CHD may be "one involved in multiple genes" with hereditary tendency. If BSS of CHD is polygenic and hereditary, gene polymorphisms may be one of the pathogens. There are some pilot researches to explore the association between gene polymorphisms and BSS of CHD. In this review, the current status of gene polymorphisms related with BSS of CHD and future perspectives are discussed.

Keywords: Chinese medicine; blood stasis syndrome; coronary heart disease; gene polymorphisms.