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. 2016:2016:7963895.
doi: 10.1155/2016/7963895. Epub 2016 Mar 3.

The Serum Concentrations of Chemokine CXCL12 and Its Specific Receptor CXCR4 in Patients with Esophageal Cancer

Marta Łukaszewicz-Zając  1 , Barbara Mroczko  2 , Mirosław Kozłowski  3 , Maciej Szmitkowski  1
Affiliations

The Serum Concentrations of Chemokine CXCL12 and Its Specific Receptor CXCR4 in Patients with Esophageal Cancer

Marta Łukaszewicz-Zając et al. Dis Markers. 2016.

Abstract

Objectives: Recent investigations have suggested that upregulated levels of inflammatory biomarkers, such as chemokines, may be associated with development of many malignancies, including esophageal cancer (EC). Based on our knowledge, this study is the first to assess the serum concentration of chemokine CXCL12 and its specific receptor CXCR4 in the diagnosis of EC patients.

Material and methods: The present study included 79 subjects: 49 patients with EC and 30 healthy volunteers. The serum concentrations of CXCL12 and CXCR4 and classical tumor markers such as carcinoembryonal antigen (CEA) and squamous cell cancer antigen (SCC-Ag) were measured using immunoenzyme assays, while C-reactive protein (CRP) levels were assessed by immunoturbidimetric method. Moreover, diagnostic criteria of all proteins tested and the survival of EC patients were assessed.

Results: The serum concentrations of CXCL12 were significantly higher, while those of its receptor CXCR4 were significantly lower in EC patients compared to healthy controls. The diagnostic sensitivity, negative predictive value, and accuracy of CXCR4 were the highest among all analyzed proteins and increased for combined analysis with classical tumor markers and CRP levels.

Conclusion: Our findings suggest that serum CXCR4 may improve the diagnosis of EC patients, especially in combination with classical tumor markers.

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Figures

Figure 1
Figure 1
Areas under ROC curves (AUC) for CXCL12 (AUC = 0.6354; p = 0.0371), CXCR4 (AUC = 0.6456; p = 0.0450), and classical tumor markers—CEA (AUC = 0.6973; p = 0.0016) and SCC-Ag (AUC = 0.5384; p = 0.552) as well as CRP (AUC = 0.7779; p < 0.001) in esophageal cancer patients.
See this image and copyright information in PMC

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