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Review
. 2016 Feb;28(1):80-91.
doi: 10.3978/j.issn.1000-9604.2016.02.09.

Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology

Tianying Xing  1 , Huiying He  1
Affiliations
Review

Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology

Tianying Xing et al. Chin J Cancer Res. 2016 Feb.

Abstract

Clear cell renal cell carcinoma (ccRCC) is one frequent form of urologic malignancy with numerous genetic and epigenetic alterations. This review summarizes the recent major findings of epigenetic alterations including DNA methylation, histone modifications, microRNAs and recently identified long noncoding RNAs in the development and progression of ccRCC. These epigenetic profilings can provide a promising means of prognostication and early diagnosis for patients with ccRCCs. With the developed high-throughput technologies nowadays, the epigenetic analyses will have possible clinical applications in the molecular pathology of ccRCC.

Keywords: DNA methylation; clear cell renal cell carcinoma (ccRCC); histone modification; long noncoding RNA; microRNA.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Epigenetic regulation in the formation and progression of ccRCC. Schematic outline of some of the epigenetic alterations, especially some important miRNAs, regulate the signaling pathways that are proposed to contribute to the proliferation, angiogenesis and metastasis of ccRCC.
See this image and copyright information in PMC

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