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Review
. 2016 Feb;28(1):99-106.
doi: 10.3978/j.issn.1000-9604.2016.01.04.

Intraductal carcinoma of prostate (IDC-P): from obscure to significant

Ni Chen  1 , Qiao Zhou  1
Affiliations
Review

Intraductal carcinoma of prostate (IDC-P): from obscure to significant

Ni Chen et al. Chin J Cancer Res. 2016 Feb.

Abstract

The concept of intraductal carcinoma of prostate (IDC-P) has evolved over the years and its clinicopathologic significance has come to be more clearly appreciated. In contrast to morphologically malignant intraductal lesions that represent earlier stages of the malignant process in other anatomic sites such as the breast, IDC-P has now been generally recognized as a prognostically unfavorable manifestation of later stage spreading of its invasive counterpart. We here briefly review the evolution of the IDC-P concept, the histological diagnostic criteria and differential diagnosis, the clinical significance, as well as recent molecular data of IDC-P.

Keywords: Intraductal carcinoma of prostate (IDC-P); diagnosis; histopathology; prognosis.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
(A-E) Representative IDC-P morphologies characterized by solid (with or without comedonecrosis), dense cribriform, or loose cribriform patterns (with comedonecrosis) (H&E, 200×); (F-J) corresponding figures of IHC with the P63/CK34β12/AMACR cocktail for each case shown in A-E, respectively, demonstrating preservation of basal cells in IDC-P. The basal cells are stained either in red or brown, depending on the kit used (IHC, 200×). IDC-P, intraductal carcinoma of prostate; IHC, immunohistochemistry.
Figure 2
Figure 2
A case of IDC-P (in association with Gleason 4+4 carcinoma). (A) H&E morphology, showing dense cribriform pattern and comedonecrosis (H&E, 200×); (B) IHC with the P63/CK34β12/AMACR cocktail, showing preservation of basal cells in the IDC-P (but not in the invasive) component (IHC, 200×); (C) both the IDC-P and invasive components are ERG positive in this case (IHC, 200×). IDC-P, intraductal carcinoma of prostate; IHC, immunohistochemistry.
See this image and copyright information in PMC

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