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. 2016 Mar;7(2):190-6.
doi: 10.1111/jdi.12382. Epub 2015 Jul 14.

Association of salivary alpha 2-macroglobulin levels and clinical characteristics in type 2 diabetes

Tsung-Ju Chung  1 , Kai-Yuen Hsu  2 , Jui-Hung Chen  2 , Jhih-Syuan Liu  2 , Hsiao-Wen Chang  2 , Peng-Fei Li  2 , Chia-Luen Huang  2 , Yi-Shing Shieh  3 , Chien-Hsing Lee  2
Affiliations

Association of salivary alpha 2-macroglobulin levels and clinical characteristics in type 2 diabetes

Tsung-Ju Chung et al. J Diabetes Investig. 2016 Mar.

Abstract

Aims/introduction: Studies suggest that salivary proteins can be used as potential non-invasive markers for clinical diagnosis and screening for diabetes. Previous reports showed that plasma alpha 2-macroglobulin (A2MG) levels were higher in diabetic patients, especially with diabetic complications. We investigated the relationship between salivary A2MG values and clinical characteristics in patients with type 2 diabetes.

Materials and methods: A total of 91 adults were recruited from our outpatient clinics. The study the patients' collected general and biochemical data, and blood glucose (fasting glucose, glycated hemoglobin [HbA1c]) data. Plasma and salivary A2MG levels were examined by enzyme-linked immunosorbent assay.

Results: The salivary A2MG levels were significantly positively correlated with plasma A2MG levels, fasting glucose HbA1c and periodontitis status. After 3 months of follow up, the net change of salivary A2MG values positively correlated with the net change of fasting glucose, HbA1c and triglyceride levels, but negatively correlated with high-density lipoprotein cholesterol changes. Furthermore, the correlations between salivary A2MG and fasting glucose HbA1c were better than plasma A2MG, respectively.

Conclusions: Our data show that salivary A2MG levels have better correlation with fasting glucose HbA1c and periodontitis status than plasma A2MG in diabetic patients. Salivary A2MG concentration might serve as a non-invasive marker for clinical diabetic control.

Keywords: Alpha 2‐macroglobulin; Diabetes; Saliva.

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Figures

Figure 1
Figure 1
Simple linear regression for the association of (a) salivary alpha 2‐macroglobulin (A2MG) with plasma glycated hemoglobin (HbA1c; r = 0.443, P < 0.001), (b) plasma A2MG with plasma HbA1c (r = 0.342, P = 0.001) and (c) salivary A2MG with plasma A2MG (r = 0.318, P = 0.002).
See this image and copyright information in PMC

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