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. 2016 Mar;7(2):197-205.
doi: 10.1111/jdi.12388. Epub 2015 Jul 27.

Influence of atherosclerosis-related risk factors on serum high-sensitivity C-reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non-obese patients

Masashi Shimoda  1 , Hideaki Kaneto  1 , Hiroshi Yoshioka  1 , Seizo Okauchi  1 , Hidenori Hirukawa  1 , Tomohiko Kimura  1 , Yukiko Kanda-Kimura  1 , Kenji Kohara  1 , Shinji Kamei  1 , Fumiko Kawasaki  2 , Tomoatsu Mune  1 , Kohei Kaku  2
Affiliations

Influence of atherosclerosis-related risk factors on serum high-sensitivity C-reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non-obese patients

Masashi Shimoda et al. J Diabetes Investig. 2016 Mar.

Abstract

Aims/introduction: Increased levels of high-sensitivity C-reactive protein (hs-CRP) likely leads to the development of atherosclerosis. Therefore, it is very important to know which factors largely influence hs-CRP levels. In the present study, we examined the influence of various atherosclerosis-related factors on hs-CRP levels in patients with type 2 diabetes.

Materials and methods: A total of 275 patients (176 men, 99 women) were enrolled in this study. We tested the relationship between the number of risk factors reaching a desired value and hs-CRP levels. The Mann-Whitney U-test was used to compare two groups. The Kruskal-Wallis test was used to carry out overall group comparisons, and the Steel-Dwass test was used to carry out between-group comparisons. Spearman's rank correlation was carried out to study the correlation between hs-CRP levels and clinical parameters. Multivariate regression method was used to analyze the factors independently contributing to hs-CRP levels.

Results: Hs-CRP levels were lower in patients with a larger number of risk factors reaching a desired value. In particular, triglyceride and body mass index (BMI) were independent risk factors determining hs-CRP levels in a multivariate regression analysis. Furthermore, we compared the influence of various factors on hs-CRP levels in both obese (BMI ≥25 kg/m(2)) and non-obese patients with type 2 diabetes (BMI <25 kg/m(2)). In obese groups, BMI and urinary albumin were independent risk factors determining hs-CRP levels, whereas triglyceride and statin were independent risk factors in non-obese patients.

Conclusions: There is some difference in the factors responsible for hs-CRP levels in obese and non-obese patients with type 2 diabetes.

Keywords: Body mass index; High‐sensitivity C‐reactive protein; Type 2 diabetes.

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Figures

Figure 1
Figure 1
Influence of the number of risk factors reaching a desired value on serum high‐sensitivity C‐reactive protein (hs‐CRP) in patients with type 2 diabetes.
Figure 2
Figure 2
(a) Correlation of body mass index (BMI) and serum high‐sensitivity C‐reactive protein (hs‐CRP) levels, (b) and correlation of triglyceride and serum hs‐CRP levels in patients with type 2 diabetes.
See this image and copyright information in PMC

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