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Case Reports
. 2016 Feb;8(2):117-20.
doi: 10.4103/1947-2714.174348.

Drug-Induced Pancreatitis: A Rare Manifestation of Doxycycline Administration

Faisal Inayat  1 , Hafeez Ul Hassan Virk  2 , Daniel J Yoon  3 , Iqra Riaz  4
Affiliations
Case Reports

Drug-Induced Pancreatitis: A Rare Manifestation of Doxycycline Administration

Faisal Inayat et al. N Am J Med Sci. 2016 Feb.

Abstract

Context: Drug-induced pancreatitis (DIP) is rare, but as there are no systematic data on it, the true incidence is not known. Although numerous and varied drugs have been associated with DIP, the clinical evidence on doxycycline-induced pancreatitis is sparse.

Case report: We present the case of a 58-year-old female who presented with complaints of nausea and severe epigastric pain. Her medications included doxycycline which she had been on for only 2 days. Computed tomography of her abdomen showed mild enlargement of body of the pancreas with peripancreatic fatty infiltration, along with lipase level suggestive of acute pancreatitis. In the absence of classical risk factors for acute pancreatitis, a diagnosis of DIP secondary to doxycycline therapy was made. Immediate withdrawal of the drug was accompanied by relief of symptoms and resolution of pancreatitis.

Conclusion: This report implicates doxycycline as an etiological factor for acute pancreatitis. Knowledge regarding doxycycline related pancreatitis is of paramount importance in order to diagnose cases early and institute effective treatment in patients who are undergoing therapy with this drug.

Keywords: Acute pancreatitis; doxycycline; drug-induced pancreatitis (DIP).

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Figures

Figure 1
Figure 1
Right upper quadrant ultrasound demonstrating mild proximal dilatation of the common bile duct with smooth tapering of the duct distally. No common bile duct stone is present
Figure 2
Figure 2
Contrast-enhanced computed tomography at the level of pancreas. Arrow demonstrates mild enlargement of the body of the pancreas
Figure 3
Figure 3
Contrast-enhanced computed tomography at the level of pancreas. Arrow in yellow color demonstrates peripancreatic fatty infiltration. Black arrowhead showed surgical clips in the gallbladder fossa indicating the patient's status after cholecystectomy
Figure 4
Figure 4
Contrast-enhanced computed tomography at the level of the pancreas performed 4 months prior to the current presentation. Normal-appearing pancreas and peripancreatic fat were demonstrated
See this image and copyright information in PMC

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