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. 2016 Apr 20;138(15):5024-7.
doi: 10.1021/jacs.6b02527. Epub 2016 Apr 7.

Enantioselective CuH-Catalyzed Hydroallylation of Vinylarenes

Yi-Ming Wang  1 , Stephen L Buchwald  1
Affiliations

Enantioselective CuH-Catalyzed Hydroallylation of Vinylarenes

Yi-Ming Wang et al. J Am Chem Soc. .

Abstract

The enantioselective, intermolecular hydroallylation of vinylarenes employing allylic phosphate electrophiles has been achieved through a copper hydride catalyzed process. The protocol described herein can be applied to a diverse set of vinylarene substrates and allows for the installation of the parent allyl group as well as a range of 2-substituted allylic fragments.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Comparison between copper-catalyzed allylic substitution and hydroallylation (A) and postulated catalytic cycle (B).
See this image and copyright information in PMC

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