Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Aug 16;165(4):301-4.
doi: 10.7326/M15-3066. Epub 2016 Apr 5.

Severe Meningoencephalitis in a Case of Ebola Virus Disease: A Case Report

Daniel S Chertow, Avindra Nath, Anthony F Suffredini, Robert L Danner, Daniel S Reich, Rachel J Bishop, Richard W Childs, Andrew E Arai, Tara N Palmore, H Clifford Lane, Anthony S Fauci, Richard T Davey
Case Reports

Severe Meningoencephalitis in a Case of Ebola Virus Disease: A Case Report

Daniel S Chertow et al. Ann Intern Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Sequential multi-organ failure in a patient with Ebola virus disease despite adequate blood pressure control: (A–E) Clinical course (A) text-boxes show approximate onset and resolution of clinical findings. Line-graph shows cycle threshold value that Ebola virus glycoprotein RNA was detected by quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in serum. Select vital signs (B) red line-graph shows maximum daily temperature, yellow line-graph shows maximum daily heart rate, and blue line-graph shows minimum daily mean arterial blood pressure. Select laboratory values (C–E). Complete blood count (C) red line-graph show hemoglobin level, yellow line-graph shows total white blood cell (WBC) count, and blue line-graph shows platelet count. Serum chemistries (D) purple line-graph shows aspartate aminotransferase (AST) level, blue line-graph shows total bilirubin level, red line-graph shows creatinine kinase level, and yellow line-graph shows serum creatinine (Cr) level. Coagulation (E) blue line-graph shows activated partial thromboplastin (aPPT) level and red line-graph shows d-dimer level.
Figure 2
Figure 2
Brain MRI following recovery from Ebola meningoencephalitis: (A–D) Initial MRI, performed on day 33. (A) T2-weighted FLAIR image showing multiple punctate high signal intensity lesions in the corpus callosum. Some of the corpus callosum lesions (B), as well as a lesion on the margin of the fourth ventricle (C), showed restriction of diffusion, compatible with microvascular occlusion and ischemia. (D) A lesion in the right lateral column of the thoracic spinal cord. (E–H)
See this image and copyright information in PMC

References

    1. Chertow DS, Kleine C, Edwards JK, Scaini R, Giuliani R, Sprecher A. Ebola virus disease in West Africa–clinical manifestations and management. N Engl - PubMed
    1. World Health Organization. Ebola situation report-21 October 2015. http://apps.who.int/ebola/current-situation/ebola-situation-report-21-oc... (Accessed on October 23, 2015)
    1. Edwards JK, Kleine C, Munster V, et al. Interpretation of Negative Molecular Test Results in Patients With Suspected or Confirmed Ebola Virus Disease: Report of Two Cases. Open Forum Infect Dis. 2015;2:ofv137. - PMC - PubMed
    1. Howlett P, Brown C, Helderman T, Brooks T, Lisk D, Deen G, et al. Ebola virus disease complicated by late-onset encephalitis and polyarthritis, Sierra Leone [letter] Emerg Infect Dis. 2016 Jan; (Cited November 11, 2015). http://dx.doi.org/10.3201/eid2201.151212. - DOI - PMC - PubMed
    1. Bechtelsheimer H, Korb G, Gedigk P. The “Marburg-virus”-hepatitis. Studies in man and guinea pigs. Virchows Arch A Pathol Pathol Anat. 1970;351:273–90. - PubMed