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Randomized Controlled Trial
. 2016 Apr 5:11:43.
doi: 10.1186/s13019-016-0437-8.

Therapeutic hypothermia in adult patients receiving extracorporeal life support: early results of a randomized controlled study

Philip Y K Pang  1 , Gillian H L Wee  2 , Anne E E Hoo  3 , Ismail Mohamed Tahir Sheriff  2 , See Lim Lim  4 , Teing Ee Tan  4 , Yee Jim Loh  4 , Ka Lee Kerk  5 , Yoong Kong Sin  4 , Chong Hee Lim  4   5
Affiliations
Randomized Controlled Trial

Therapeutic hypothermia in adult patients receiving extracorporeal life support: early results of a randomized controlled study

Philip Y K Pang et al. J Cardiothorac Surg. .

Abstract

Cardiac arrest with cerebral ischaemia frequently leads to severe neurological impairment. Extracorporeal life support (ECLS) has emerged as a valuable adjunct in resuscitation of cardiac arrest. Despite ECLS, the incidence of permanent neurological injury remains high. We hypothesize that patients receiving ECLS for cardiac arrest treated with therapeutic hypothermia at 34 °C have lower neurological complication rates compared to standard ECLS therapy at normothermia. Early results of this randomized study suggest that therapeutic hypothermia is safe in adult patients receiving ECLS, with similar complication rates as ECLS without hypothermia. Further studies are warranted to measure the efficacy of this therapy.

Keywords: Cardiac arrest; Extracorporeal life support; Therapeutic hypothermia.

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