Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2016 Apr 4;6(4):e010929.
doi: 10.1136/bmjopen-2015-010929.

Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol

Katrin A Dias  1 , Jeff S Coombes  1 , Daniel J Green  2 , Sjaan R Gomersall  1 , Shelley E Keating  1 , Arnt Erik Tjonna  3 , Siri Marte Hollekim-Strand  3 , Mansoureh Sadat Hosseini  3 , Torstein Baade Ro  4 , Margrete Haram  5 , Else Marie Huuse  3 , Peter S W Davies  6 , Peter A Cain  7 , Gary M Leong  8 , Charlotte B Ingul  3
Affiliations
Randomized Controlled Trial

Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol

Katrin A Dias et al. BMJ Open. .

Abstract

Introduction: The prevalence of paediatric obesity is increasing, and with it, lifestyle-related diseases in children and adolescents. High-intensity interval training (HIIT) has recently been explored as an alternate to traditional moderate-intensity continuous training (MICT) in adults with chronic disease and has been shown to induce a rapid reversal of subclinical disease markers in obese children and adolescents. The primary aim of this study is to compare the effects of HIIT with MICT on myocardial function in obese children and adolescents.

Methods and analysis: Multicentre randomised controlled trial of 100 obese children and adolescents in the cities of Trondheim (Norway) and Brisbane (Australia). The trial will examine the efficacy of HIIT to improve cardiometabolic outcomes in obese children and adolescents. Participants will be randomised to (1) HIIT and nutrition advice, (2) MICT and nutrition advice or (3) nutrition advice. Participants will partake in supervised exercise training and/or nutrition sessions for 3 months. Measurements for study end points will occur at baseline, 3 months (postintervention) and 12 months (follow-up). The primary end point is myocardial function (peak systolic tissue velocity). Secondary end points include vascular function (flow-mediated dilation assessment), quantity of visceral and subcutaneous adipose tissue, myocardial structure and function, body composition, cardiorespiratory fitness, autonomic function, blood biochemistry, physical activity and nutrition. Lean, healthy children and adolescents will complete measurements for all study end points at one time point for comparative cross-sectional analyses.

Ethics and dissemination: This randomised controlled trial will generate substantial information regarding the effects of exercise intensity on paediatric obesity, specifically the cardiometabolic health of this at-risk population. It is expected that communication of results will allow for the development of more effective evidence-based exercise prescription guidelines in this population while investigating the benefits of HIIT on subclinical markers of disease.

Trial registration number: NCT01991106.

Keywords: High intensity interval training; Myocardial function; NUTRITION & DIETETICS; Paediatric obesity; Vascular function; Visceral adipose tissue.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Intervention groups/stratification.
Figure 2
Figure 2
A scheme illustrating a time schedule for enrolment, intervention and assessment of obese participants.
See this image and copyright information in PMC

References

    1. Cole TJ, Lobstein T. Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. Pediatr Obes 2012;7:284–94. 10.1111/j.2047-6310.2012.00064.x - DOI - PubMed
    1. Freedman DS, Khan LK, Serdula MK et al. . The relation of childhood BMI to adult adiposity: the Bogalusa Heart Study. Pediatrics 2005;115:22–7. 10.1542/peds.2004-0220 - DOI - PubMed
    1. World Health Organization. Global status report on noncommunicable diseases. Global status report on noncommunicable diseases 2011. http://www.who.int/nmh/publications/ncd_report_full_en.pdf
    1. Webber L, Divajeva D, Marsh T et al. . The future burden of obesity-related diseases in the 53 WHO European-Region countries and the impact of effective interventions: a modelling study. BMJ Open 2014;4:e004787 10.1136/bmjopen-2014-004787 - DOI - PMC - PubMed
    1. Poirier P, Giles TD, Bray GA et al. . Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006;113:898–918. doi:10.1161/CIRCULATIONAHA.106.17101610.1136/bmjopen-2014-004787 - DOI - PubMed

Publication types

Associated data