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Editorial
. 2016 Sep;29(3):354-63.
doi: 10.1177/0394632016643550. Epub 2016 Apr 4.

Obesity and kidney disease: Beyond the hyperfiltration

A Mascali  1 , O Franzese  1 , S Nisticò  2 , U Campia  3 , D Lauro  4 , C Cardillo  5 , N Di Daniele  1 , M Tesauro  1
Affiliations
Editorial

Obesity and kidney disease: Beyond the hyperfiltration

A Mascali et al. Int J Immunopathol Pharmacol. 2016 Sep.

Abstract

In industrialized countries, overweight and obesity account for approximately 13.8% and 24.9% of the kidney disease observed in men and women, respectively. Moreover, obesity-associated glomerulopathy is now considered as "an emerging epidemic." Kidney function can be negatively impacted by obesity through several mechanisms, either direct or indirect. While it is well established that obesity represents the leading risk factor for type 2 diabetes and hypertension, awareness that obesity is associated with direct kidney damage independently of hypertension and diabetes is still not widespread. In this paper we will discuss the emerging role of adipose tissue, particularly in the visceral depot, in obesity-induced chronic kidney damage.

Keywords: hyperfiltration; kidney disease; obesity.

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Conflict of interest statement

Declaration of conflicting interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The Hyperfiltration Model.
Figure 2.
Figure 2.
Kidney Damage Mechanisms.
See this image and copyright information in PMC

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