Clinical use of statins in hematopoietic stem cell transplantation: Old drugs and new horizons

Review

. 2016 Jan 1;10(1):42-50.

Clinical use of statins in hematopoietic stem cell transplantation: Old drugs and new horizons

Mehdi Mohammadi¹, Mohammad Vaezi², Bahador Mirrahimi³, Molouk Hadjibabaie⁴

Affiliations

¹ Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
² Hematology-Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
³ Clinical Pharmacy Department, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran; Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 27047650
PMCID: PMC4818788

Review

Clinical use of statins in hematopoietic stem cell transplantation: Old drugs and new horizons

Mehdi Mohammadi et al. Int J Hematol Oncol Stem Cell Res. 2016.

. 2016 Jan 1;10(1):42-50.

Authors

Mehdi Mohammadi¹, Mohammad Vaezi², Bahador Mirrahimi³, Molouk Hadjibabaie⁴

Affiliations

¹ Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
² Hematology-Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
³ Clinical Pharmacy Department, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran; Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 27047650
PMCID: PMC4818788

Abstract

Hydroxymethylglutaryl Co-enzyme A reductase inhibitors, also known as statins, are a class of anti-hyperlipidemic agents. These drugs have been employed vastly to reduce the morbidity and mortality of cardiovascular disorders. Soon after their introduction, benefits other than their primary actions were discovered. Along with these pleiotropic properties, a series of mainly favorable effects has been proposed in patients intended to undergo hematopoietic stem cell transplantation. These actions address some complications encountered by this special population such as graft-versus-host disease, efficacy of chemotherapy, infections, etc. This review presents the current evidence surrounding these issues.

Keywords: GvHD; Infection; Statin; Stem cell transplantation.

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References

1. Shimabukuro-Vornhagen A, Glossmann J, Liebig T, et al. The use of statins in hematopoietic stem cell transplantation. Curr Stem Cell Res Ther. 2009;4(4):260–5. - PubMed
1. Dhir S, Slatter M, Skinner R. Recent advances in the management of graft-versus-host disease. Arch Dis Child. 2014;99(12):1150–7. e-pub ahead of print 12 Jul 2014; doi: 10.1136/archdischild-2013-304832. - PubMed
1. Lucena CM, Torres A, Rovira M, et al. Pulmonary complications in hematopoietic SCT: a prospective study. Bone Marrow Transplant. 2014;49(10):1293–9. e-pub ahead of print 21 Jul 2014; doi: 10.1038/bmt.2014.151. - PMC - PubMed
1. Servais S, Lengline E, Porcher R, et al. Long-term immune reconstitution and infection burden after mismatched hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2014;20(4):507–17. - PubMed
1. Rotta M, Storer BE, Storb R, et al. Impact of recipient statin treatment on graft-versus-host disease after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2010;16(10):1463–6. - PMC - PubMed

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[1] Shimabukuro-Vornhagen A, Glossmann J, Liebig T, et al. The use of statins in hematopoietic stem cell transplantation. Curr Stem Cell Res Ther. 2009;4(4):260–5. - PubMed

[2] Shimabukuro-Vornhagen A, Glossmann J, Liebig T, et al. The use of statins in hematopoietic stem cell transplantation. Curr Stem Cell Res Ther. 2009;4(4):260–5. - PubMed

[3] Dhir S, Slatter M, Skinner R. Recent advances in the management of graft-versus-host disease. Arch Dis Child. 2014;99(12):1150–7. e-pub ahead of print 12 Jul 2014; doi: 10.1136/archdischild-2013-304832. - PubMed

[4] Dhir S, Slatter M, Skinner R. Recent advances in the management of graft-versus-host disease. Arch Dis Child. 2014;99(12):1150–7. e-pub ahead of print 12 Jul 2014; doi: 10.1136/archdischild-2013-304832. - PubMed

[5] Lucena CM, Torres A, Rovira M, et al. Pulmonary complications in hematopoietic SCT: a prospective study. Bone Marrow Transplant. 2014;49(10):1293–9. e-pub ahead of print 21 Jul 2014; doi: 10.1038/bmt.2014.151. - PMC - PubMed

[6] Lucena CM, Torres A, Rovira M, et al. Pulmonary complications in hematopoietic SCT: a prospective study. Bone Marrow Transplant. 2014;49(10):1293–9. e-pub ahead of print 21 Jul 2014; doi: 10.1038/bmt.2014.151. - PMC - PubMed

[7] Servais S, Lengline E, Porcher R, et al. Long-term immune reconstitution and infection burden after mismatched hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2014;20(4):507–17. - PubMed

[8] Servais S, Lengline E, Porcher R, et al. Long-term immune reconstitution and infection burden after mismatched hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2014;20(4):507–17. - PubMed

[9] Rotta M, Storer BE, Storb R, et al. Impact of recipient statin treatment on graft-versus-host disease after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2010;16(10):1463–6. - PMC - PubMed

[10] Rotta M, Storer BE, Storb R, et al. Impact of recipient statin treatment on graft-versus-host disease after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2010;16(10):1463–6. - PMC - PubMed

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Clinical use of statins in hematopoietic stem cell transplantation: Old drugs and new horizons

Affiliations

Clinical use of statins in hematopoietic stem cell transplantation: Old drugs and new horizons

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