Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;25(10):2579-2592.
doi: 10.1007/s11136-016-1282-x. Epub 2016 Apr 5.

Predictors of health-related quality of life in people with a complex chronic disease including multimorbidity: a longitudinal cohort study

Zephanie Tyack  1   2   3 , Kerrie-Anne Frakes  4 , Adrian Barnett  5 , Petrea Cornwell  6   7 , Suzanne Kuys  7   8 , Steven McPhail  5   9
Affiliations

Predictors of health-related quality of life in people with a complex chronic disease including multimorbidity: a longitudinal cohort study

Zephanie Tyack et al. Qual Life Res. 2016 Oct.

Abstract

Purpose: Factors that predict the health-related quality of life (HRQoL) of people with complex chronic diseases have not been investigated to date. Determining the impact of disease on daily activities is a factor that is particularly important with this group of people. This study examined the influence of a range of predictors (including the impact of chronic diseases on daily activities), on HRQoL in patients with complex chronic diseases over a 12-month period.

Method: A longitudinal cohort study was conducted with outcomes measured at baseline, 3, 6 and 12 months post-baseline. Adults attending an Australian community-based rehabilitation service were included. HRQoL was measured using the SF-36 and corresponding preference-based health utility. Predictor variables included sociodemographic factors, disease factors (e.g. impact of diseases on daily activities), intervention factors, psychosocial factors and HRQoL components that were not included as the dependent variable. Linear mixed-effects regression was used to examine the relationship between predictor variables and HRQoL.

Results: Data from 351 participants were included. The impact of chronic disease on daily activities was the most frequent significant predictor of HRQoL outcomes. Other significant predictors included the impact of chronic back pain or sciatica on daily activities, the number of comorbidities, general health functioning and psychological distress.

Conclusion: Models of health care for people with complex chronic disease may be enhanced by greater focus on patients' daily activities during assessment and intervention delivery. The range of significant predictors highlights the importance of an interdisciplinary team for managing complex chronic disease or targeted intervention strategies.

Keywords: Chronic disease; Comorbidity; Health-related quality of life; Interdisciplinary; Multimorbidity; Rehabilitation.

PubMed Disclaimer

References

    1. J Card Fail. 2011 Jan;17(1):47-53 - PubMed
    1. Qual Life Res. 2004 Mar;13(2):283-98 - PubMed
    1. Qual Life Res. 2006 Feb;15(1):83-91 - PubMed
    1. J Epidemiol Community Health. 2007 Mar;61(3):254-61 - PubMed
    1. Qual Life Res. 2014 Jun;23(5):1543-56 - PubMed

LinkOut - more resources