Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Apr 6;8(1):36.
doi: 10.1186/s13073-016-0292-1.

Mood by microbe: towards clinical translation

Timothy G Dinan  1   2 , John F Cryan  3   4
Affiliations
Review

Mood by microbe: towards clinical translation

Timothy G Dinan et al. Genome Med. .

Abstract

There is a growing realization that the gut-brain axis plays a key role in maintaining brain health and the stress response. Recently, the gut microbiota has emerged as a master regulator of this axis. Thus, opportunities to exploit the microbiome to treat stress-related psychiatric disorders are materializing. Clinical validation of such strategies is now warranted.

PubMed Disclaimer

References

    1. Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012;13(10):701–12. doi: 10.1038/nrn3346. - DOI - PubMed
    1. Sampson TR, Mazmanian SK. Control of brain development, function, and behavior by the microbiome. Cell Host Microbe. 2015;17(5):565–76. doi: 10.1016/j.chom.2015.04.011. - DOI - PMC - PubMed
    1. Dinan TG, Stanton C, Cryan JF. Psychobiotics: a novel class of psychotropic. Biol Psychiatry. 2013;74(10):720–6. doi: 10.1016/j.biopsych.2013.05.001. - DOI - PubMed
    1. Collins SM, Kassam Z, Bercik P. The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications. Curr Opin Microbiol. 2013;16(3):240–5. doi: 10.1016/j.mib.2013.06.004. - DOI - PubMed
    1. Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, et al. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol. 2004;558(Pt 1):263–75. doi: 10.1113/jphysiol.2004.063388. - DOI - PMC - PubMed

Publication types