doi: 10.1111/j.1600-0722.1989.tb01448.x.
Potentiation of fibroblast DNA synthesis by a phenytoin-induced mononuclear cell derived factor in vitro
Affiliations
- PMID: 2704979
- DOI: 10.1111/j.1600-0722.1989.tb01448.x
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Potentiation of fibroblast DNA synthesis by a phenytoin-induced mononuclear cell derived factor in vitro
Scand J Dent Res.
1989 Apr.
Abstract
Human mononuclear cells purified by Lymphoprep flotation were incubated with phenytoin (PHT) (20 micrograms/ml) or its metabolite p-HPPH (2 micrograms/ml) in the presence of Concanavalin A (10 micrograms/ml) in vitro. The results indicate that phenytoin and its metabolite p-HPPH induce the release of a mononuclear cell factor(s) that activates quiescent human gingival fibroblast to synthesize DNA.
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