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. 1989 Apr;97(2):186-7.
doi: 10.1111/j.1600-0722.1989.tb01448.x.

Potentiation of fibroblast DNA synthesis by a phenytoin-induced mononuclear cell derived factor in vitro

T Modéer  1 , G Dahllöf, J Karsten, P Otteskog
Affiliations

Potentiation of fibroblast DNA synthesis by a phenytoin-induced mononuclear cell derived factor in vitro

T Modéer et al. Scand J Dent Res. 1989 Apr.

Abstract

Human mononuclear cells purified by Lymphoprep flotation were incubated with phenytoin (PHT) (20 micrograms/ml) or its metabolite p-HPPH (2 micrograms/ml) in the presence of Concanavalin A (10 micrograms/ml) in vitro. The results indicate that phenytoin and its metabolite p-HPPH induce the release of a mononuclear cell factor(s) that activates quiescent human gingival fibroblast to synthesize DNA.

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