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Editorial
. 2016 Aug;13(8):1045-8.
doi: 10.1517/17425247.2016.1171841. Epub 2016 Apr 8.

Low-frequency ultrasound for drug delivery in the gastrointestinal tract

Carl M Schoellhammer  1   2 , Giovanni Traverso  1   2   3
Affiliations
Editorial

Low-frequency ultrasound for drug delivery in the gastrointestinal tract

Carl M Schoellhammer et al. Expert Opin Drug Deliv. 2016 Aug.
No abstract available

Keywords: Drug delivery; gastrointestinal drug delivery; inflammatory bowel disease; oral delivery; physical enhancer; sonophoresis; transient cavitation; ulcerative colitis; ultrasound.

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Figures

Figure 1
Figure 1. Ultrasound-mediated Gastrointestinal Drug Delivery
Macroscopic (A) and microscopic (B) view of the use of ultrasound in the colon for the treatment of inflamed mucosa in the setting of ulcerative colitis. i) Treatment is started by inserting the enema syringe into the colon. ii) When treatment is started, the enema is instilled in the colon and low-frequency ultrasound nucleates cavitation bubbles, which implode and drive microjets of drug (light blue) into the inflamed tissue. iii) After treatment, the device is removed and the drug begins to reduce inflammation. iv) After a course of treatment, inflammation is resolved.
See this image and copyright information in PMC

Comment on

  • Ultrasound-mediated gastrointestinal drug delivery.
    Schoellhammer CM, Schroeder A, Maa R, Lauwers GY, Swiston A, Zervas M, Barman R, DiCiccio AM, Brugge WR, Anderson DG, Blankschtein D, Langer R, Traverso G. Schoellhammer CM, et al. Sci Transl Med. 2015 Oct 21;7(310):310ra168. doi: 10.1126/scitranslmed.aaa5937. Sci Transl Med. 2015. PMID: 26491078 Free PMC article.

References

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