Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 May:101:213-20.
doi: 10.1016/j.critrevonc.2016.03.017. Epub 2016 Mar 30.

Learning from the "tsunami" of immune checkpoint inhibitors in 2015

Hampig Raphael Kourie  1 , Gil Awada  2 , Ahmad Hussein Awada  3
Affiliations
Review

Learning from the "tsunami" of immune checkpoint inhibitors in 2015

Hampig Raphael Kourie et al. Crit Rev Oncol Hematol. 2016 May.

Abstract

2015 was marked by the tsunami of immune checkpoint inhibitors revealed by numerous FDA approvals, publications and abstracts in relation with these drugs in different cancers and settings. First, we reported all new indications of anti-CTLA4 and anti-PD1 approved by the FDA, the positive clinical trials published and the abstracts with promising results at important scientific meetings during 2015. Then, we discussed different critical issues of these new agents going from their predictive factors, combination therapies, tumor response patterns, efficacy in particular settings, side effect management to cost and economic burden.

Keywords: 2015; Cancer; Immune checkpoint inhibitors; Round up; Treatment.

PubMed Disclaimer

LinkOut - more resources