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Review
. 2016 Jan;9(1):91-100.
doi: 10.14202/vetworld.2016.91-100. Epub 2016 Jan 29.

Potential of acute phase proteins as predictor of postpartum uterine infections during transition period and its regulatory mechanism in dairy cattle

A Manimaran  1 , A Kumaresan  2 , S Jeyakumar  1 , T K Mohanty  2 , V Sejian  1 , Narender Kumar  1 , L Sreela  3 , M Arul Prakash  3 , P Mooventhan  3 , A Anantharaj  1 , D N Das  1
Affiliations
Review

Potential of acute phase proteins as predictor of postpartum uterine infections during transition period and its regulatory mechanism in dairy cattle

A Manimaran et al. Vet World. 2016 Jan.

Abstract

Among the various systemic reactions against infection or injury, the acute phase response is the cascade of reaction and mostly coordinated by cytokines-mediated acute phase proteins (APPs) production. Since APPs are sensitive innate immune molecules, they are useful for early detection of inflammation in bovines and believed to be better discriminators than routine hematological parameters. Therefore, the possibility of using APPs as a diagnostic and prognostic marker of inflammation in major bovine health disorders including postpartum uterine infection has been explored by many workers. In this review, we discussed specifically importance of postpartum uterine infection, the role of energy balance in uterine infections and potential of APPs as a predictor of postpartum uterine infections during the transition period and its regulatory mechanism in dairy cattle.

Keywords: bovine uterine infections; cute phase proteins; negative energy balance; pro-inflammatory cytokines; transition period.

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Figures

Figure-1
Figure-1
Effects of negative energy balance on reproductive function. Up arrow indicate increase while down arrows indicate a decrease.
Figure-2
Figure-2
Acute phase responses. ­increase, ¯decrease.
See this image and copyright information in PMC

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