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Case Reports
. 2015 Jul 25;1(5):247-50.
doi: 10.1016/j.jdcr.2015.05.006. eCollection 2015 Sep.

Verrucous sarcoidosis associated with human papillomavirus infection: A case report

Michael Noparstak  1 , Brianna McDaniel  2 , Joy King  3 , Robert T Brodell  4 , Peter Rady  5 , Ramya Killipara  6 , Stephen Tyring  7
Affiliations
Case Reports

Verrucous sarcoidosis associated with human papillomavirus infection: A case report

Michael Noparstak et al. JAAD Case Rep. .
No abstract available

Keywords: HPV, human papillomavirus; PCR, polymerase chain reaction; VS, verrucous sarcoidosis; cutaneous sarcoidosis; human papillomavirus; immunocompromised district; sarcoidosis; verruca vulgaris; verrucous sarcoidosis.

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Figures

Fig 1
Fig 1
A, An annular verrucous plaque with central clearing slowly expanded over several years after blunt trauma to the bridge of the nose. B, Scattered 1- to 8-mm hyperpigmented dermal papules and plaques without scaling on the cheeks.
Fig 2
Fig 2
A, Epidermis shows papillomatous architecture with hyperkeratosis and acanthosis. Parakeratosis overlies digitate projections (left pointing arrow) of epithelium. Hypergranulosis with vacuolization presents between the projections. A sarcoidal granuloma (downward arrow) is noted in the upper dermis. B, Sarcoidal granulomas with multinucleated giant cells are surrounded by a sprinkling of lymphocytes. (A and B, Hematoxylin-eosin stain; original magnifications: A, ×40; B, ×100.)
Fig 3
Fig 3
A, The patient's DNA was positive with β-globin PCR assay. B, The patient's sample was positive with FAP-nested PCR assay designed primarily for the detection of cutaneous HPVs. C, National Center for Biotechnology Information Basic Local Alignment Search Tool analysis of DNA sequence information obtained from the 235 base pair–sized HPV-PCR product found the presence of FA14 HPV isolate in the patient's sample.
Fig 4
Fig 4
A, Expansion of the original annular verrucous lesion. Two newer-appearing annular verrucous lesions, one just lateral to the left nasolabial fold and the other superior to the left lateral eyebrow arose in pre-existing sarcoidal plaques. Note the improvement in the background cutaneous sarcoidosis papules and plaques. (Compare with Fig 1, A and B.) B, Close-up view of the annular verrucous lesion along the right nasal sidewall. C, Close-up view of the annular verrucous lesion superior to the left lateral eyebrow.
See this image and copyright information in PMC

References

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